Source:http://linkedlifedata.com/resource/pubmed/id/15819801
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2005-4-11
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| pubmed:abstractText |
Post-transplant circulating anti-human leukocyte antigens (HLA)-antibodies and C4d in allograft biopsies may be important in chronic rejection in renal transplant recipients (RTR). We determined the prevalence and significance of anti-HLA-antibodies and donor-specific antibodies (DSA). Sera were collected from 251 RTR >6 months post-transplant. Sera were tested using enzyme-linked immunosorbent assay (ELISA) screening for anti-HLA antibodies. Positive sera were retested with ELISA-specific panel for antibody specificity. A 11.2% of patients had anti-HLA antibodies and 4.4% had DSA. Anti-HLA antibodies were significantly associated with pretransplant sensitization, acute rejection and in multivariate analysis, higher serum creatinine (2.15 +/- 0.98 vs. 1.57 +/- 0.69 mg/dl in negative anti-HLA antibodies group). Allograft biopsies performed in a subset of patients with anti-HLA antibodies revealed that 66% had C4d in peritubular capillaries (0% in patients without antibodies). Anti-HLA antibodies were associated with a worse allograft function and in situ evidence of anti-donor humoral alloreactivity. Long-term RTR with an increase in creatinine could be screened for anti-HLA antibodies and C4d in biopsy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Complement C4b,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/complement C4d
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0934-0874
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
532-40
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15819801-Adolescent,
pubmed-meshheading:15819801-Adult,
pubmed-meshheading:15819801-Aged,
pubmed-meshheading:15819801-Aged, 80 and over,
pubmed-meshheading:15819801-Antibody Specificity,
pubmed-meshheading:15819801-Child,
pubmed-meshheading:15819801-Child, Preschool,
pubmed-meshheading:15819801-Chronic Disease,
pubmed-meshheading:15819801-Complement C4b,
pubmed-meshheading:15819801-Cross-Sectional Studies,
pubmed-meshheading:15819801-Female,
pubmed-meshheading:15819801-Graft Rejection,
pubmed-meshheading:15819801-HLA Antigens,
pubmed-meshheading:15819801-Humans,
pubmed-meshheading:15819801-Isoantibodies,
pubmed-meshheading:15819801-Kidney Transplantation,
pubmed-meshheading:15819801-Male,
pubmed-meshheading:15819801-Middle Aged,
pubmed-meshheading:15819801-Peptide Fragments,
pubmed-meshheading:15819801-Time Factors,
pubmed-meshheading:15819801-Tissue Donors
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| pubmed:year |
2005
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| pubmed:articleTitle |
Prevalence and significance of anti-HLA and donor-specific antibodies long-term after renal transplantation.
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| pubmed:affiliation |
Clinica Medica e Nefrologia, Universita degli Studi di Parma, Parma, Italy. cardarelli.francesca@asmn.re.it
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|