Source:http://linkedlifedata.com/resource/pubmed/id/15817819
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2005-5-25
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| pubmed:abstractText |
Cytochrome P450 2D6 (CYP2D6) is one of the best-known polymorphic drug-metabolizing enzymes. Rapidly evolving genotyping techniques permit the identification of single-nucleotide polymorphisms (SNPs) and thereby a prediction of individual metabolic capacities for CYP2D6 substrates. A considerable part of interindividual variability in CYP2D6 enzyme activity, however, is not related to SNPs but to gene deletions and duplications. Currently used genotyping methods assume that these gene rearrangements are homogeneous.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0009-9147
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
939-43
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| pubmed:meshHeading |
pubmed-meshheading:15817819-Cytochrome P-450 CYP2D6,
pubmed-meshheading:15817819-Gene Deletion,
pubmed-meshheading:15817819-Gene Duplication,
pubmed-meshheading:15817819-Gene Frequency,
pubmed-meshheading:15817819-Genotype,
pubmed-meshheading:15817819-Heterozygote,
pubmed-meshheading:15817819-Humans,
pubmed-meshheading:15817819-Male,
pubmed-meshheading:15817819-Polymerase Chain Reaction,
pubmed-meshheading:15817819-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15817819-Polymorphism, Single Nucleotide,
pubmed-meshheading:15817819-Risk
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| pubmed:year |
2005
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| pubmed:articleTitle |
Identification of subtypes of CYP2D gene rearrangements among carriers of CYP2D6 gene deletion and duplication.
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| pubmed:affiliation |
Genetics Unit, Hospital Perpetuo Socorro, Badajoz, Spain.
|
| pubmed:publicationType |
Journal Article
|