| pubmed-article:1581772 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1581772 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:1581772 | lifeskim:mentions | umls-concept:C0199236 | lld:lifeskim |
| pubmed-article:1581772 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:1581772 | lifeskim:mentions | umls-concept:C0151449 | lld:lifeskim |
| pubmed-article:1581772 | lifeskim:mentions | umls-concept:C1420806 | lld:lifeskim |
| pubmed-article:1581772 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:1581772 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1581772 | pubmed:dateCreated | 1992-6-16 | lld:pubmed |
| pubmed-article:1581772 | pubmed:abstractText | A study of HLA and primary Sjögren's syndrome (1 degree SS) was performed in 40 index cases and 180 relatives all of whom were Caucasian. The association of DR3 and 1 degree SS was confirmed. In probands, DR3 associated with extraglandular manifestations of 1 degree SS and homozygosity for DR3 associated with younger onset of disease. Familial clustering of 1 degree SS was evident. Definite or probable 1 degree SS (Fox criteria) occurred with a prevalence of 4.4% in the relatives, exclusively in older female first degree relatives and was associated with DR3. The relative risk was greatest in those who expressed anti-nuclear factor, rheumatoid factor or Ro and DR3. We identified a group of young females expressing some criteria for 1 degree SS and the same immunogenetic markers. They may be at risk of full expression of 1 degree SS as they become older. Milder forms of 1 degree SS were common in older relatives but not DR3 associated. 1 degree SS in males was rare and mild irrespective of immunogenetic status. Symptoms of 1 degree SS in relatives were mild or absent. Such individuals will only be identified through a family study or a community survey. | lld:pubmed |
| pubmed-article:1581772 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1581772 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1581772 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1581772 | pubmed:month | May | lld:pubmed |
| pubmed-article:1581772 | pubmed:issn | 0263-7103 | lld:pubmed |
| pubmed-article:1581772 | pubmed:author | pubmed-author:WalkerDD | lld:pubmed |
| pubmed-article:1581772 | pubmed:author | pubmed-author:FosterHH | lld:pubmed |
| pubmed-article:1581772 | pubmed:author | pubmed-author:CharlesPP | lld:pubmed |
| pubmed-article:1581772 | pubmed:author | pubmed-author:KellyCC | lld:pubmed |
| pubmed-article:1581772 | pubmed:author | pubmed-author:GriffithsII | lld:pubmed |
| pubmed-article:1581772 | pubmed:author | pubmed-author:CavanaghGG | lld:pubmed |
| pubmed-article:1581772 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1581772 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:1581772 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1581772 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1581772 | pubmed:pagination | 309-14 | lld:pubmed |
| pubmed-article:1581772 | pubmed:dateRevised | 2007-5-11 | lld:pubmed |
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| pubmed-article:1581772 | pubmed:meshHeading | pubmed-meshheading:1581772-... | lld:pubmed |
| pubmed-article:1581772 | pubmed:meshHeading | pubmed-meshheading:1581772-... | lld:pubmed |
| pubmed-article:1581772 | pubmed:meshHeading | pubmed-meshheading:1581772-... | lld:pubmed |
| pubmed-article:1581772 | pubmed:meshHeading | pubmed-meshheading:1581772-... | lld:pubmed |
| pubmed-article:1581772 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1581772 | pubmed:articleTitle | Association of DR3 with susceptibility to and severity of primary Sjögren's syndrome in a family study. | lld:pubmed |
| pubmed-article:1581772 | pubmed:affiliation | Department of Rheumatology, Royal Victoria Infirmary, Newcastle upon Tyne. | lld:pubmed |
| pubmed-article:1581772 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1581772 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
