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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-6-16
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pubmed:abstractText |
A study of HLA and primary Sjögren's syndrome (1 degree SS) was performed in 40 index cases and 180 relatives all of whom were Caucasian. The association of DR3 and 1 degree SS was confirmed. In probands, DR3 associated with extraglandular manifestations of 1 degree SS and homozygosity for DR3 associated with younger onset of disease. Familial clustering of 1 degree SS was evident. Definite or probable 1 degree SS (Fox criteria) occurred with a prevalence of 4.4% in the relatives, exclusively in older female first degree relatives and was associated with DR3. The relative risk was greatest in those who expressed anti-nuclear factor, rheumatoid factor or Ro and DR3. We identified a group of young females expressing some criteria for 1 degree SS and the same immunogenetic markers. They may be at risk of full expression of 1 degree SS as they become older. Milder forms of 1 degree SS were common in older relatives but not DR3 associated. 1 degree SS in males was rare and mild irrespective of immunogenetic status. Symptoms of 1 degree SS in relatives were mild or absent. Such individuals will only be identified through a family study or a community survey.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0263-7103
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-14
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pubmed:dateRevised |
2007-5-11
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pubmed:meshHeading |
pubmed-meshheading:1581772-Adolescent,
pubmed-meshheading:1581772-Adult,
pubmed-meshheading:1581772-Aged,
pubmed-meshheading:1581772-Aged, 80 and over,
pubmed-meshheading:1581772-Autoantigens,
pubmed-meshheading:1581772-Disease Susceptibility,
pubmed-meshheading:1581772-Female,
pubmed-meshheading:1581772-Genetic Markers,
pubmed-meshheading:1581772-HLA-DR3 Antigen,
pubmed-meshheading:1581772-Homozygote,
pubmed-meshheading:1581772-Humans,
pubmed-meshheading:1581772-Incidence,
pubmed-meshheading:1581772-Male,
pubmed-meshheading:1581772-Middle Aged,
pubmed-meshheading:1581772-RNA, Small Cytoplasmic,
pubmed-meshheading:1581772-Ribonucleoproteins,
pubmed-meshheading:1581772-Risk Factors,
pubmed-meshheading:1581772-Severity of Illness Index,
pubmed-meshheading:1581772-Sjogren's Syndrome
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pubmed:year |
1992
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pubmed:articleTitle |
Association of DR3 with susceptibility to and severity of primary Sjögren's syndrome in a family study.
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pubmed:affiliation |
Department of Rheumatology, Royal Victoria Infirmary, Newcastle upon Tyne.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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