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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
8
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pubmed:dateCreated |
2005-4-7
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pubmed:abstractText |
Bacillus anthracis secretes two critical virulence factors, lethal toxin (LT) and edema toxin (ET). In this study, we show that murine bone marrow-derived dendritic cells (DC) infected with B. anthracis strains secreting ET exhibit a very different cytokine secretion pattern than DC infected with B. anthracis strains secreting LT, both toxins, or a nontoxinogenic strain. ET produced during infection selectively inhibits the production of IL-12p70 and TNF-alpha, whereas LT targets IL-10 and TNF-alpha production. To confirm the direct role of the toxins, we show that purified ET and LT similarly disrupt cytokine secretion by DC infected with a nontoxinogenic strain. These effects can be reversed by specific inhibitors of each toxin. Furthermore, ET inhibits in vivo IL-12p70 and IFN-gamma secretion induced by LPS. These results suggest that ET produced during infection impairs DC functions and cooperates with LT to suppress the innate immune response. This may represent a new strategy developed by B. anthracis to escape the host immune response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4934-41
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pubmed:dateRevised |
2009-9-4
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pubmed:meshHeading |
pubmed-meshheading:15814721-Adenylate Cyclase,
pubmed-meshheading:15814721-Animals,
pubmed-meshheading:15814721-Antigens, Bacterial,
pubmed-meshheading:15814721-Bacillus anthracis,
pubmed-meshheading:15814721-Bacterial Toxins,
pubmed-meshheading:15814721-Cytokines,
pubmed-meshheading:15814721-Dendritic Cells,
pubmed-meshheading:15814721-Interleukin-10,
pubmed-meshheading:15814721-Interleukin-12,
pubmed-meshheading:15814721-Male,
pubmed-meshheading:15814721-Mice,
pubmed-meshheading:15814721-Mice, Inbred BALB C,
pubmed-meshheading:15814721-Mice, Inbred C57BL,
pubmed-meshheading:15814721-Protein Subunits,
pubmed-meshheading:15814721-Spores, Bacterial,
pubmed-meshheading:15814721-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells.
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pubmed:affiliation |
Département de Biologie des Agents Transmissibles, Centre de Recherches du Service de Santé des Armées, La Tronche Cedex, France. jntournier@crssa.net
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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