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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021051,
umls-concept:C0021756,
umls-concept:C0025260,
umls-concept:C0037224,
umls-concept:C0039215,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205099,
umls-concept:C0277785,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2005-4-7
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pubmed:abstractText |
Production of IL-2 and IFN-gamma by CD4+ T lymphocytes is important for the maintenance of a functional immune system in infected individuals. In the present study, we assessed the cytokine production profiles of functionally distinct subsets of CD4+ T lymphocytes in rhesus monkeys infected with pathogenic or attenuated SIV/simian human immunodeficiency virus (SHIV) isolates, and these responses were compared with those in vaccinated monkeys that were protected from immunodeficiency following pathogenic SHIV challenge. We observed that preserved central memory CD4+ T lymphocyte production of SIV/SHIV-induced IL-2 was associated with disease protection following primate lentivirus infection. Persisting clinical protection in vaccinated and challenged monkeys is thus correlated with a preserved capacity of the peripheral blood central memory CD4+ T cells to express this important immunomodulatory cytokine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AIDS Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/SAIDS Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AciernoPaula MPM,
pubmed-author:BarouchDan HDH,
pubmed-author:BeaudryKristin RKR,
pubmed-author:GorgoneDarci ADA,
pubmed-author:LetvinNorman LNL,
pubmed-author:LiftonMichelle AMA,
pubmed-author:LingXuX,
pubmed-author:MaeckerHolden THT,
pubmed-author:MansonKelledyK,
pubmed-author:MascolaJohn RJR,
pubmed-author:NabelGary JGJ,
pubmed-author:PanicaliDennisD,
pubmed-author:PhilipponValerieV,
pubmed-author:SantraSampaS,
pubmed-author:SchmitzJörn EJE,
pubmed-author:SubbramanianRamu ARA,
pubmed-author:SunYueY
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4753-60
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15814700-AIDS Vaccines,
pubmed-meshheading:15814700-Animals,
pubmed-meshheading:15814700-Antigens, CD28,
pubmed-meshheading:15814700-Antigens, CD95,
pubmed-meshheading:15814700-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15814700-Gene Products, gag,
pubmed-meshheading:15814700-HIV,
pubmed-meshheading:15814700-HIV Infections,
pubmed-meshheading:15814700-Humans,
pubmed-meshheading:15814700-Immunologic Memory,
pubmed-meshheading:15814700-Interferon-gamma,
pubmed-meshheading:15814700-Interleukin-2,
pubmed-meshheading:15814700-Macaca mulatta,
pubmed-meshheading:15814700-RNA, Viral,
pubmed-meshheading:15814700-SAIDS Vaccines,
pubmed-meshheading:15814700-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:15814700-Simian immunodeficiency virus,
pubmed-meshheading:15814700-T-Lymphocyte Subsets,
pubmed-meshheading:15814700-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.
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pubmed:affiliation |
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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