Linked Life Data

15808924

Source:http://linkedlifedata.com/resource/pubmed/id/15808924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-4-5
pubmed:abstractText
Male wild house mice selectively bred for long and short attack latency (LAL and SAL, respectively) were previously shown to respond differently to chronic sensory contact stress with another SAL male. In the present study, it was investigated whether the genotype of the opponent played a role in the differential stress response of LAL and SAL mice. To this end, a LAL or SAL male was housed either under standard conditions (i.e. with a female), single, or in sensory contact with another LAL or SAL male for a period of 5 days. This period was chosen in order to study stress response adaptations. Although social isolation (singly housed) already induced changes in some physiological markers, in particular in LAL mice, the highest number of stress-induced changes was observed in LAL and SAL males living opposite a male of the other genotype. This was indicated in LAL mice by higher corticosterone levels, adrenal hypertrophy, and reduced seminal vesicle weight, and in SAL mice by higher ACTH levels and adrenal hypertrophy. Some mechanisms through which LAL and SAL mice could perceive each other as being different are proposed in the discussion, but it remains unclear why these mice show a differential stress response depending on the genotype of the opponent. In conclusion, it was demonstrated that a psychosocial stressor triggered line-specific changes in LAL and SAL mice, which were shown to be determined by the genotype of the stressor. These results open a new avenue to investigate mechanisms underlying genotypic-dependent stress responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0306-4530
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
550-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The stress response to sensory contact in mice: genotype effect of the stimulus animal.
pubmed:affiliation
Department of Animal Physiology, Center for Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands. alexa.veenema@biologie.uni-regensburg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't