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pubmed:abstractText |
Though Dnmt1 is considered the primary maintenance methyltransferase and Dnmt3a and Dnmt3b are considered de novo methyltransferases in mammals, these three enzymes may work together in maintaining as well as establishing DNA methylation patterns. It has been proposed that Dnmt1 may carry out de novo methylation at sites in the genome with transient single-stranded regions, such as replication origins, and then spread methylation from these nucleation sites in vivo, even though such activity has not been reported.
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pubmed:affiliation |
Department of Urology, University of Southern California, 1441 Eastlake Ave,, Rm 5420, Norris Cancer Center, Los Angeles, CA 90033, USA. hsieh_c@ccnt.hsc.usc.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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