15798206

Source:http://linkedlifedata.com/resource/pubmed/id/15798206

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019652, umls-concept:C0871261, umls-concept:C0879590, umls-concept:C1155065, umls-concept:C1704632, umls-concept:C1706817, umls-concept:C2911692
pubmed:issue	8
pubmed:dateCreated	2005-3-30
pubmed:abstractText	Several models have been proposed for the mechanism of chromatin remodelling across the promoters of inducible genes in mammalian cells. The most commonly held model is one of cooccupation where histone proteins are modified by acetylation or phosphorylation and nucleosomes are remodelled, allowing the assembly of transcription factor complexes. Using chromatin immunoprecipitation, we observed an apparent decrease of histone acetylation and phosphorylation signals at the proximal promoter region of the inducible interleukin-2 and granulocyte-macrophage colony-stimulating factor genes in response to T-cell activation. We showed that this apparent decrease was due to a loss of histone H3 and H4 proteins corresponding to a decrease in nucleosome occupation of the promoter. This histone loss is reversible; it is dependent on the continual presence of appropriate activating signals and transcription factors and is not dependent on the acetylation status of the histone proteins. These data show for the first time that histone proteins are lost from a mammalian promoter upon activation of transcription and support a model of activation-dependent disassembly and reassembly of nucleosomes.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8109087
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage..., http://linkedlifedata.com/resource/pubmed/chemical/Histones, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Nucleosomes, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0270-7306
pubmed:author	pubmed-author:ChenXinxinX, pubmed-author:GerondakisSteveS, pubmed-author:ShannonM FrancesMF, pubmed-author:WangJunJ, pubmed-author:WoltringDonnaD
pubmed:issnType	Print
pubmed:volume	25
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3209-19
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:15798206-Acetylation, pubmed-meshheading:15798206-Animals, pubmed-meshheading:15798206-Cells, Cultured, pubmed-meshheading:15798206-Chromatin Assembly and Disassembly, pubmed-meshheading:15798206-Chromatin Immunoprecipitation, pubmed-meshheading:15798206-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:15798206-Histones, pubmed-meshheading:15798206-Interleukin-2, pubmed-meshheading:15798206-Lymphocyte Activation, pubmed-meshheading:15798206-Mice, pubmed-meshheading:15798206-Nucleosomes, pubmed-meshheading:15798206-Phosphorylation, pubmed-meshheading:15798206-Promoter Regions, Genetic, pubmed-meshheading:15798206-T-Lymphocytes, pubmed-meshheading:15798206-Transcription Factors, pubmed-meshheading:15798206-Transcriptional Activation
pubmed:year	2005
pubmed:articleTitle	Histone dynamics on the interleukin-2 gene in response to T-cell activation.
pubmed:affiliation	Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

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