Source:http://linkedlifedata.com/resource/pubmed/id/15793779
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2005-3-28
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pubmed:abstractText |
Alpha-2 macroglobulin (alpha2M) is a proteinase inhibitor found in association with senile plaques in Alzheimer's disease (AD). Also alpha2M has been implicated in several pathophysiological processes in AD. In view of the recent contradictory reports on the relationship between AD and a common polymorphism I1000V in A2M gene, the present authors studied a relatively large sample, determined the genotype of the I1000V polymorphism in A2M gene in sporadic AD patients and age-matched controls with normal cognition, and examined the possible association of the polymorphism with AD.
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pubmed:language |
chi
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1003-9406
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
174-9
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pubmed:meshHeading |
pubmed-meshheading:15793779-Aged,
pubmed-meshheading:15793779-Aged, 80 and over,
pubmed-meshheading:15793779-Alzheimer Disease,
pubmed-meshheading:15793779-Apolipoproteins E,
pubmed-meshheading:15793779-Asian Continental Ancestry Group,
pubmed-meshheading:15793779-China,
pubmed-meshheading:15793779-Female,
pubmed-meshheading:15793779-Gene Frequency,
pubmed-meshheading:15793779-Genetic Predisposition to Disease,
pubmed-meshheading:15793779-Genotype,
pubmed-meshheading:15793779-Humans,
pubmed-meshheading:15793779-Male,
pubmed-meshheading:15793779-Middle Aged,
pubmed-meshheading:15793779-Polymerase Chain Reaction,
pubmed-meshheading:15793779-Polymorphism, Genetic,
pubmed-meshheading:15793779-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15793779-alpha-Macroglobulins
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pubmed:year |
2005
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pubmed:articleTitle |
[No evidence for genetic association between alpha-2 macroglobulin I1000V polymorphism and sporadic Alzheimer's disease in two independent Chinese populations].
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pubmed:affiliation |
Department of Medical Genetics, West China Hospital, Sichuan University, Division of Human Morbid Genomics, State Key Laboratory of Biotherapy of Human Diseases, Chengdu, Sichuan, 610041 P. R. China.
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pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
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