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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-3-28
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pubmed:abstractText |
Two patients with myasthenia gravis (Ossermann IIb) involving invasive thymoma who underwent extensive thymectomy manifested myasthenic crisis shortly after the procedure; however, both patients were treated with intravenous immunoglobulin and recovered from myasthenic crisis that had been deteriorating for about 1 week. Subsequently, the patients were administered a low-dose of tacrolimus (3 mg/day) in addition to prednisolone. Several months later, tacrolimus continued to control fluctuations of myasthenic symptoms and maintained remission in these patients. The serum titer of anti-Ach-receptor antibodies decreased in parallel with clinical improvement due to tacrolimus, and we accordingly reduced the dosage of prednisolone. Tacrolimus is a new immunosuppressive agent acting through the selective inhibition of helper-T-cell activation that can be reduced dosage of steroids and can maintain remission of myasthenia gravis with invasive thymoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
231
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-8
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pubmed:meshHeading |
pubmed-meshheading:15792826-Adult,
pubmed-meshheading:15792826-Antibodies,
pubmed-meshheading:15792826-Antineoplastic Agents, Hormonal,
pubmed-meshheading:15792826-Drug Interactions,
pubmed-meshheading:15792826-Humans,
pubmed-meshheading:15792826-Immunoglobulins, Intravenous,
pubmed-meshheading:15792826-Immunosuppressive Agents,
pubmed-meshheading:15792826-Male,
pubmed-meshheading:15792826-Middle Aged,
pubmed-meshheading:15792826-Myasthenia Gravis,
pubmed-meshheading:15792826-Neoplasm Invasiveness,
pubmed-meshheading:15792826-Prednisolone,
pubmed-meshheading:15792826-Receptors, Cholinergic,
pubmed-meshheading:15792826-Recurrence,
pubmed-meshheading:15792826-Tacrolimus,
pubmed-meshheading:15792826-Thymectomy,
pubmed-meshheading:15792826-Thymoma,
pubmed-meshheading:15792826-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Low-dose tacrolimus for two cases of myasthenia gravis with invasive thymoma that relapsed shortly after thymectomy.
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pubmed:affiliation |
Third Departement of Internal Medicine, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, 761-0793 Kagawa, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports
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