Linked Life Data

1579055

Source:http://linkedlifedata.com/resource/pubmed/id/1579055

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-6-11
pubmed:abstractText
To test for a regulatory defect in adipose triacylglycerol (essential) fatty acid mobilization in lymphoma-bearing mice, free [1-14C]linoleic acid/mouse serum albumin was injected iv into lymphoma-bearing and control mice, adapted to a reversed light cycle, and studied in three dietary states in the dark period. Mean daily food intake decreased in mice with small and large tumor burdens. Plasma free fatty acid (FFA) oxidation rates, which approximate FFA mobilization rates, were estimated by multicompartmental analysis (CONSAM). Oxidation of linoleate to CO2 was reduced significantly (85%) in ad libitum fed as compared to briefly fasted control mice but not in fed vs. fasted mice with large or small tumor burdens. However, plasma FFA oxidation rates to CO2 did not differ in briefly fasted tumor-bearing and pair-fed control mice. When re-fed a 250-mg test meal, briefly fasted mice with small tumors suppressed plasma free linoleic acid oxidation, as did controls. During simulated night, mildly anorexic, tumor-bearing mice with small tumor burdens mobilized essential fatty acids much faster than controls. This could explain body fat loss. The abnormally rapid rates of FFA (free linoleic acid) mobilization at night probably result from anorexia rather than from inability of food to suppress fat mobilization.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0024-4201
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Anorexic contribution to increased linoleate mobilization and oxidation in lymphoma-bearing mice.
pubmed:affiliation
Liver Research Laboratory, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.