Linked Life Data

15789272

Source:http://linkedlifedata.com/resource/pubmed/id/15789272

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-3-24
pubmed:abstractText
Lanreotide Autogel (Ipsen) is a long-acting somatostatin analogue (SA) in a new galenic formulation suitable for subcutaneous (s.c.) injection. In our department, 11 patients with therapy-resistant acromegaly were treated with Lanreotide Autogel for 48 months. 10/11 patients had previously undergone transsphenoidal surgery. For a median duration of 1.4 years prior to Lanreotide Autogel, the patients received Lanreotide PR 30 mg every 7, 10, or 14 days. 60, 90, or 120 mg of Lanreotide Autogel was administered by deep s.c. injection every 28 days, with the higher dosage being given to those with the previously shortest injection interval under Lanreotide PR. Dose was adjusted on the basis of Growth Hormone (GH) level after 4, 8, and 12 months with a minimum dose of 60 mg and a maximum dose of 120 mg. The efficacy of Lanreotide Autogel treatment was evaluated by measuring GH concentrations (4 hour profiles) and IGF-I levels. Before switching to Lanreotide Autogel, the multiple of the upper limit of normal (xULN) of IGF-I levels was 1.2 (median) and the median GH level was 1.3 microg/l. 3 out of 11 patients had an IGF-I within the age- and sex-adjusted normal range. After 48 months of treatment with Lanreotide Autogel, six patients had an IGF-I within the normal range. Median GH levels were at 1.3 microg/l and xULN of IGF-I was at 1.0 compared to Lanreotide PR 30 mg treatment (p < 0.001). At the end of the study, 8 patients received 120 mg Lanreotide Autogel, 2 patients 90 mg and 1 patient 60 mg, respectively. There was slight but significant deterioration of glucose metabolism with an increase of HbA1c. In conclusion, the new galenic formulation of Lanreotide improves not only the control of biochemical markers of acromegaly compared to the conventional PR formulation, but is also easier to administer given its deep s.c. method of administration. Glucose metabolism has to be followed carefully in patients on high-dose Lanreotide Autogel.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0947-7349
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-44
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15789272-Acromegaly, pubmed-meshheading:15789272-Aged, pubmed-meshheading:15789272-Clinical Trials as Topic, pubmed-meshheading:15789272-Delayed-Action Preparations, pubmed-meshheading:15789272-Dose-Response Relationship, Drug, pubmed-meshheading:15789272-Drug Administration Schedule, pubmed-meshheading:15789272-Female, pubmed-meshheading:15789272-Follow-Up Studies, pubmed-meshheading:15789272-Gallbladder, pubmed-meshheading:15789272-Gallstones, pubmed-meshheading:15789272-Gels, pubmed-meshheading:15789272-Hemoglobin A, Glycosylated, pubmed-meshheading:15789272-Humans, pubmed-meshheading:15789272-Injections, Subcutaneous, pubmed-meshheading:15789272-Insulin-Like Growth Factor I, pubmed-meshheading:15789272-Lipids, pubmed-meshheading:15789272-Male, pubmed-meshheading:15789272-Middle Aged, pubmed-meshheading:15789272-Multicenter Studies as Topic, pubmed-meshheading:15789272-Peptides, Cyclic, pubmed-meshheading:15789272-Somatostatin, pubmed-meshheading:15789272-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
Four-year follow-up of acromegalic patients treated with the new long-acting formulation of Lanreotide (Lanreotide Autogel).
pubmed:affiliation
Department of Internal Medicine Innenstadt, University of Munich, Germany. Bodo.Gutt@med.uni-muenchen.de
pubmed:publicationType
Journal Article