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rdf:type |
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lifeskim:mentions |
umls-concept:C0003015,
umls-concept:C0013216,
umls-concept:C0030705,
umls-concept:C0053091,
umls-concept:C0055673,
umls-concept:C0085580,
umls-concept:C0149721,
umls-concept:C0332293,
umls-concept:C0439849,
umls-concept:C0678951,
umls-concept:C0684321,
umls-concept:C1333402,
umls-concept:C2603343
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pubmed:issue |
1
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pubmed:dateCreated |
2005-3-24
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pubmed:abstractText |
About 15-37% of the adult population worldwide suffers from hypertension. Hypertension is responsible for one-third of all global deaths. Left ventricular hypertrophy (LVH) is one of the most important characteristics of hypertension target organ damage and is also an independent risk factor for cardiovascular events. Therefore, effective regression of LVH is a main aim of hypertension treatment and also an important public health concern. However, few studies of the regression of LVH have been reported. In particular, little is known about the relationship between the genotypes of angiotensin-converting enzyme (ACE) and chymase (CMA) genes, and the effectiveness of antihypertensive drugs in regression of LVH.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-4460
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
30-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15788353-Adult,
pubmed-meshheading:15788353-Aged,
pubmed-meshheading:15788353-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:15788353-Benzazepines,
pubmed-meshheading:15788353-Blood Pressure,
pubmed-meshheading:15788353-Chymases,
pubmed-meshheading:15788353-Female,
pubmed-meshheading:15788353-Genotype,
pubmed-meshheading:15788353-Humans,
pubmed-meshheading:15788353-Hypertension,
pubmed-meshheading:15788353-Hypertrophy, Left Ventricular,
pubmed-meshheading:15788353-Male,
pubmed-meshheading:15788353-Middle Aged,
pubmed-meshheading:15788353-Peptidyl-Dipeptidase A,
pubmed-meshheading:15788353-Polymerase Chain Reaction,
pubmed-meshheading:15788353-Polymorphism, Genetic,
pubmed-meshheading:15788353-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:15788353-Serine Endopeptidases,
pubmed-meshheading:15788353-Treatment Outcome
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pubmed:articleTitle |
A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril.
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pubmed:affiliation |
Institute of Health Studies, School of Sociology and Population Studies, 59 Zhang Guan Cun Street, Beijing, 100872, China. hehong99@hotmail.com
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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