Linked Life Data

15781306

Source:http://linkedlifedata.com/resource/pubmed/id/15781306

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-3-22
pubmed:abstractText
Are the linguistic forms that are memorized in the mental lexicon and those that are specified by the rules of grammar subserved by distinct neurocognitive systems or by a single computational system with relatively broad anatomic distribution? On a dual-system view, the productive -ed-suffixation of English regular past tense forms (e.g., look-looked) depends upon the mental grammar, whereas irregular forms (e.g., dig-dug) are retrieved from lexical memory. On a single-mechanism view, the computation of both past tense types depends on associative memory. Neurological double dissociations between regulars and irregulars strengthen the dual-system view. The computation of real and novel, regular and irregular past tense forms was investigated in 20 aphasic subjects. Aphasics with non-fluent agrammatic speech and left frontal lesions were consistently more impaired at the production, reading, and judgment of regular than irregular past tenses. Aphasics with fluent speech and word-finding difficulties, and with left temporal/temporo-parietal lesions, showed the opposite pattern. These patterns held even when measures of frequency, phonological complexity, articulatory difficulty, and other factors were held constant. The data support the view that the memorized words of the mental lexicon are subserved by a brain system involving left temporal/temporo-parietal structures, whereas aspects of the mental grammar, in particular the computation of regular morphological forms, are subserved by a distinct system involving left frontal structures.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0093-934X
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-238; discussion 239-42
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15781306-Adult, pubmed-meshheading:15781306-Aged, pubmed-meshheading:15781306-Anomia, pubmed-meshheading:15781306-Aphasia, Broca, pubmed-meshheading:15781306-Aphasia, Wernicke, pubmed-meshheading:15781306-Attention, pubmed-meshheading:15781306-Brain Mapping, pubmed-meshheading:15781306-Diagnostic Imaging, pubmed-meshheading:15781306-Dominance, Cerebral, pubmed-meshheading:15781306-Dyslexia, pubmed-meshheading:15781306-Electroencephalography, pubmed-meshheading:15781306-Female, pubmed-meshheading:15781306-Frontal Lobe, pubmed-meshheading:15781306-Humans, pubmed-meshheading:15781306-Male, pubmed-meshheading:15781306-Memory, Short-Term, pubmed-meshheading:15781306-Mental Recall, pubmed-meshheading:15781306-Middle Aged, pubmed-meshheading:15781306-Nerve Net, pubmed-meshheading:15781306-Parietal Lobe, pubmed-meshheading:15781306-Reference Values, pubmed-meshheading:15781306-Statistics as Topic, pubmed-meshheading:15781306-Temporal Lobe, pubmed-meshheading:15781306-Verbal Behavior, pubmed-meshheading:15781306-Verbal Learning
pubmed:year
2005
pubmed:articleTitle
Neural correlates of lexicon and grammar: evidence from the production, reading, and judgment of inflection in aphasia.
pubmed:affiliation
Brain and Language Lab, Department of Neuroscience, Georgetown University, USA. micheal@georgetown.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural