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| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0596995 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0017019 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:1577858 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:1577858 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1577858 | pubmed:dateCreated | 1992-6-11 | lld:pubmed |
| pubmed-article:1577858 | pubmed:abstractText | We have examined the role of feedback-regulation in the expression of the nonmuscle actin genes. C2 mouse myoblasts were transfected with the human beta- and gamma-actin genes. In gamma-actin transfectants we found that the total actin mRNA and protein pools remained unchanged. Increasing levels of human gamma-actin expression resulted in a progressive down-regulation of mouse beta- and gamma-actin mRNAs. Transfection of the beta-actin gene resulted in an increase in the total actin mRNA and protein pools and induced an increase in the levels of mouse beta-actin mRNA. In contrast, transfection of a beta-actin gene carrying a single-point mutation (beta sm) produced a feedback-regulatory response similar to that of the gamma-actin gene. Expression of a beta-actin gene encoding an unstable actin protein had no impact on the endogenous mouse actin genes. This suggests that the nature of the encoded actin protein determines the feedback-regulatory response of the mouse genes. The role of the actin cytoskeleton in mediating this feedback-regulation was evaluated by disruption of the actin network with Cytochalasin D. We found that treatment with Cytochalasin D abolished the down-regulation of mouse gamma-actin in both the gamma- and beta sm-actin transfectants. In contrast, a similar level of increase was observed for the mouse beta-actin mRNA in both control and transfected cells. These experiments suggest that the down-regulation of mouse gamma-actin mRNA is dependent on the organization of the actin cytoskeleton. In addition, the mechanism responsible for the down-regulation of beta-actin may be distinct from that governing gamma-actin. We conclude that actin feedback-regulation provides a biochemical assay for differences between the two nonmuscle actin genes. | lld:pubmed |
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| pubmed-article:1577858 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1577858 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1577858 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1577858 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1577858 | pubmed:month | May | lld:pubmed |
| pubmed-article:1577858 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:1577858 | pubmed:author | pubmed-author:LloydCC | lld:pubmed |
| pubmed-article:1577858 | pubmed:author | pubmed-author:GunningPP | lld:pubmed |
| pubmed-article:1577858 | pubmed:author | pubmed-author:SchevzovGG | lld:pubmed |
| pubmed-article:1577858 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1577858 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:1577858 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1577858 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1577858 | pubmed:pagination | 787-97 | lld:pubmed |
| pubmed-article:1577858 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:1577858 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1577858 | pubmed:articleTitle | Transfection of nonmuscle beta- and gamma-actin genes into myoblasts elicits different feedback regulatory responses from endogenous actin genes. | lld:pubmed |
| pubmed-article:1577858 | pubmed:affiliation | Cell Biology Unit, Children's Medical Research Foundation, Camperdown, N.S.W., Australia. | lld:pubmed |
| pubmed-article:1577858 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1577858 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1577858 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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