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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0036341,
umls-concept:C0086860,
umls-concept:C0183683,
umls-concept:C0205245,
umls-concept:C0231449,
umls-concept:C0344211,
umls-concept:C0936012,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1415299,
umls-concept:C1521721,
umls-concept:C1556094,
umls-concept:C1882417
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pubmed:issue |
2
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pubmed:dateCreated |
2005-3-18
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pubmed:abstractText |
Dysfunction of the N-methyl-D-aspartate (NMDA) type glutamate receptor has been proposed as a mechanism in the etiology of schizophrenia. Recently, we identified a variable (GT)n repeat in the promoter region of the NMDA NR2A subunit gene (GRIN2A), and showed its association with schizophrenia in a case-control study, together with a correlation between the length of the repeat and severity of chronic outcome. In this study, we extended our analyses, by increasing the number of case-control samples to a total of 672 schizophrenics and 686 controls, and excluded potential sample stratification effects. We confirmed the significant allelic association between the repeat polymorphism and disease (P = 0.011), and as in the previous study, we observed an over-representation of longer alleles in schizophrenia. These results suggest a probable genetic effect for the GRIN2A promoter (GT)n variation on the predisposition to schizophrenia in Japanese cohorts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
378
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
102-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15774266-Adult,
pubmed-meshheading:15774266-Chi-Square Distribution,
pubmed-meshheading:15774266-Cohort Studies,
pubmed-meshheading:15774266-Dinucleotide Repeats,
pubmed-meshheading:15774266-Female,
pubmed-meshheading:15774266-Genetic Predisposition to Disease,
pubmed-meshheading:15774266-Humans,
pubmed-meshheading:15774266-Japan,
pubmed-meshheading:15774266-Male,
pubmed-meshheading:15774266-Middle Aged,
pubmed-meshheading:15774266-Polymorphism, Genetic,
pubmed-meshheading:15774266-Promoter Regions, Genetic,
pubmed-meshheading:15774266-Protein Subunits,
pubmed-meshheading:15774266-RNA, Messenger,
pubmed-meshheading:15774266-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:15774266-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15774266-Schizophrenia
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pubmed:year |
2005
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pubmed:articleTitle |
Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia.
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pubmed:affiliation |
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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