Linked Life Data

15773348

Source:http://linkedlifedata.com/resource/pubmed/id/15773348

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-3-18
pubmed:abstractText
Gene therapy for advanced breast cancer is expected to be useful therapeutic approach. Strategies in ongoing clinical protocols can be divided into four: (1) suppression of oncogenes or transduction of tumor suppressor genes; (2) enhancement of immunological response; (3) transduction of suicide genes; (4) protection of bone marrow using drug resistance gene. We have started clinical study of multidrug resistance (mdr1) gene therapy. Advanced breast cancer patients received high dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT) with mdr1-transduced hematopoietic cells, and then were treated with docetaxel. 2 patients have been treated so far, and in vivo enrichment of mdr1-transduced cells with docetaxel treatment was seen. Both patients are in complete remission and have no apparent adverse effect from mdr1 gene transduction.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
476-82
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
[Gene therapy for breast cancer].
pubmed:affiliation
Department of Medical Oncology, Cancer Institute Hospital.
pubmed:publicationType
Journal Article, English Abstract, Review