Linked Life Data

1577129

Source:http://linkedlifedata.com/resource/pubmed/id/1577129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-6-10
pubmed:abstractText
Anterograde axonal transport was studied in a new model of hexacarbon neuropathy, in which neurofilament (NF)-containing giant axonal swellings are induced proximally in the spinal nerve roots of rats by intrathecal injection of 2,5-hexanedione (2,5-HD). Decreased transport velocity of the NF-containing slow component a (SCa) was demonstrated in 2,5-HD-treated animals, in contrast to studies demonstrating increased velocity of SCa in proximal parts of the axon in systemic 2,5-HD intoxication, which causes distal axonal swellings. Other components of anterograde transport were unaffected. In systemic 2,5-HD toxicity, velocity of NF transport increases in the proximal axon, but may decrease distally, where it is difficult to study. Decreased NF transport is likely to be responsible for the formation of axonal swellings, since they occur preterminally rather than at the axon terminal as would be expected if increased NF transport were the cause. Covalent modification of proteins provides a possible mechanism by which 2,5-HD affects axonal transport, and the effect may be facilitatory or inhibitory depending on the level and duration of exposure of the NF to the toxin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
210-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Slow axonal transport is impaired by intrathecal 2,5-hexanedione.
pubmed:affiliation
Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't