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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-16
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pubmed:abstractText |
Cardiovascular surgical procedures with extracorporeal circulation (ECC) lead to neutrophil activation followed by the release of proteases such as neutrophil elastase (NE) and oxidants. The mis-balance between proteases and their physiological inhibitors may contribute to morbidity in the postoperative period. In this study, the effects of cardiac surgery on neutrophil mediators were evaluated. Release of neutrophil elastase and plasma levels of the natural NE antagonists alpha (1)-proteinase inhibitor (API) and secretory leukocyte proteinase inhibitor (SLPI) were measured. The oxidative burst and the phagocytic activity were also evaluated. Tissue destruction was quantified by measuring the serum concentration of fibronectin.
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pubmed:language |
ger
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0939-2661
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
164-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15770560-Aged,
pubmed-meshheading:15770560-Cardiac Surgical Procedures,
pubmed-meshheading:15770560-Coronary Artery Bypass,
pubmed-meshheading:15770560-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:15770560-Extracorporeal Circulation,
pubmed-meshheading:15770560-Fibronectins,
pubmed-meshheading:15770560-Flow Cytometry,
pubmed-meshheading:15770560-Granulocytes,
pubmed-meshheading:15770560-Humans,
pubmed-meshheading:15770560-Leukocyte Elastase,
pubmed-meshheading:15770560-Macrophage Activation,
pubmed-meshheading:15770560-Male,
pubmed-meshheading:15770560-Middle Aged,
pubmed-meshheading:15770560-Phagocytosis,
pubmed-meshheading:15770560-Protease Inhibitors,
pubmed-meshheading:15770560-Proteinase Inhibitory Proteins, Secretory,
pubmed-meshheading:15770560-Proteins,
pubmed-meshheading:15770560-Respiratory Burst,
pubmed-meshheading:15770560-Secretory Leukocyte Peptidase Inhibitor,
pubmed-meshheading:15770560-alpha 1-Antitrypsin
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pubmed:year |
2005
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pubmed:articleTitle |
[Activation of granulocytes and antiproteases in open heart surgery].
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pubmed:affiliation |
Abteilung für Anaesthesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Giessen. Ingeborg.D.Welters@chiru.med.uni-giessen.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
English Abstract
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