| pubmed-article:15766669 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15766669 | lifeskim:mentions | umls-concept:C1817740 | lld:lifeskim |
| pubmed-article:15766669 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15766669 | pubmed:dateCreated | 2005-3-15 | lld:pubmed |
| pubmed-article:15766669 | pubmed:abstractText | MHC specificity in positive selection is a major determinant in the CD4/CD8 T cell lineage decision. Previous studies support the view that quantitative differences in T cell receptor (TCR) signaling in immature CD4+CD8+ double positive thymocytes leads to an instructive bias in CD4/CD8 T cell lineage commitment that must be re-inforced in subsequent selection steps to ensure that MHC-restricted antigen recognition is linked to appropriate effector functions in mature T cells. Recent work has further defined the TCR signaling pathways involved in this process, but a major effort has been made to identify transcription factors and other regulators of CD4 and CD8 T cell lineage commitment. Methods and screens for detecting changes in gene expression, associated with TCR signaling in positive selection and lineage determination, are starting to provide a better understanding of these complex developmental processes. | lld:pubmed |
| pubmed-article:15766669 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15766669 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766669 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15766669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766669 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15766669 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15766669 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15766669 | pubmed:issn | 0952-7915 | lld:pubmed |
| pubmed-article:15766669 | pubmed:author | pubmed-author:FowlkesB JBJ | lld:pubmed |
| pubmed-article:15766669 | pubmed:author | pubmed-author:LakyKarenK | lld:pubmed |
| pubmed-article:15766669 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15766669 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:15766669 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15766669 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15766669 | pubmed:pagination | 116-21 | lld:pubmed |
| pubmed-article:15766669 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:meshHeading | pubmed-meshheading:15766669... | lld:pubmed |
| pubmed-article:15766669 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15766669 | pubmed:articleTitle | Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment. | lld:pubmed |
| pubmed-article:15766669 | pubmed:affiliation | Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. klaky@niaid.nih.gov | lld:pubmed |
| pubmed-article:15766669 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15766669 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15766669 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15766669 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15766669 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15766669 | lld:pubmed |
