Source:http://linkedlifedata.com/resource/pubmed/id/15766669
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2005-3-15
|
pubmed:abstractText |
MHC specificity in positive selection is a major determinant in the CD4/CD8 T cell lineage decision. Previous studies support the view that quantitative differences in T cell receptor (TCR) signaling in immature CD4+CD8+ double positive thymocytes leads to an instructive bias in CD4/CD8 T cell lineage commitment that must be re-inforced in subsequent selection steps to ensure that MHC-restricted antigen recognition is linked to appropriate effector functions in mature T cells. Recent work has further defined the TCR signaling pathways involved in this process, but a major effort has been made to identify transcription factors and other regulators of CD4 and CD8 T cell lineage commitment. Methods and screens for detecting changes in gene expression, associated with TCR signaling in positive selection and lineage determination, are starting to provide a better understanding of these complex developmental processes.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0952-7915
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
116-21
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:15766669-Animals,
pubmed-meshheading:15766669-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15766669-CD8-Positive T-Lymphocytes,
pubmed-meshheading:15766669-Cell Differentiation,
pubmed-meshheading:15766669-Gene Expression Regulation,
pubmed-meshheading:15766669-Humans,
pubmed-meshheading:15766669-Membrane Proteins,
pubmed-meshheading:15766669-Receptors, Notch,
pubmed-meshheading:15766669-Signal Transduction,
pubmed-meshheading:15766669-T-Lymphocyte Subsets
|
pubmed:year |
2005
|
pubmed:articleTitle |
Receptor signals and nuclear events in CD4 and CD8 T cell lineage commitment.
|
pubmed:affiliation |
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. klaky@niaid.nih.gov
|
pubmed:publicationType |
Journal Article,
Review
|