| pubmed-article:1576590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C0699791 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C0010711 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C0020402 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1576590 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1576590 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1576590 | pubmed:dateCreated | 1992-6-10 | lld:pubmed |
| pubmed-article:1576590 | pubmed:abstractText | The cytotoxicity of 1-beta-D-arabinofuranosylcytosine (ara-C) in combination with hydroxyurea (HU) or 2'-deoxyguanosine (GdR) on human gastric carcinoma MK-1 cells and colon carcinoma HT-15 cells was studied. Synergistic interaction between ara-C and HU on MK-1 cells and HT-15 cells, or ara-C and GdR on MK-1 cells was shown using the combination index method. HU increased the accumulation of ara-C triphosphate (ara-CTP) in the acid-soluble pool and diminished the cellular deoxyCTP (dCTP) pool. HU had no effect on the incorporation of ara-C into DNA and RNA. These results indicate that HU-induced elevation in ara-CTP and decrease in dCTP are the basis for synergy among ara-C and HU in MK-1 cells. GdR diminished cellular dCTP slightly, but it decreased the accumulation of ara-CTP in the acid-soluble pool and did not increase the incorporation of ara-C into DNA. On the other hand, ara-C increased cellular deoxyGTP (dGTP) level in the presence of GdR. These results indicate that synergy between ara-C and GdR is mediated through increased cellular dGTP which might inhibit DNA synthesis directly. | lld:pubmed |
| pubmed-article:1576590 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1576590 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576590 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1576590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1576590 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1576590 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:1576590 | pubmed:author | pubmed-author:MatsumotoMM | lld:pubmed |
| pubmed-article:1576590 | pubmed:author | pubmed-author:YamamuraMM | lld:pubmed |
| pubmed-article:1576590 | pubmed:author | pubmed-author:TsudaMM | lld:pubmed |
| pubmed-article:1576590 | pubmed:author | pubmed-author:KawaharaTT | lld:pubmed |
| pubmed-article:1576590 | pubmed:author | pubmed-author:OhkuboTT | lld:pubmed |
| pubmed-article:1576590 | pubmed:author | pubmed-author:KamiguchiHH | lld:pubmed |
| pubmed-article:1576590 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1576590 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:1576590 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:1576590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1576590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1576590 | pubmed:pagination | 221-8 | lld:pubmed |
| pubmed-article:1576590 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1576590 | pubmed:meshHeading | pubmed-meshheading:1576590-... | lld:pubmed |
| pubmed-article:1576590 | pubmed:meshHeading | pubmed-meshheading:1576590-... | lld:pubmed |
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| pubmed-article:1576590 | pubmed:meshHeading | pubmed-meshheading:1576590-... | lld:pubmed |
| pubmed-article:1576590 | pubmed:meshHeading | pubmed-meshheading:1576590-... | lld:pubmed |
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| pubmed-article:1576590 | pubmed:meshHeading | pubmed-meshheading:1576590-... | lld:pubmed |
| pubmed-article:1576590 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1576590 | pubmed:articleTitle | Synergistic inhibition of human gastric carcinoma cell growth by 1-beta-D-arabinofuranosylcytosine and hydroxyurea or 2'-deoxyguanosine in vitro. | lld:pubmed |
| pubmed-article:1576590 | pubmed:affiliation | Department of Biochemistry, Tokai University School of Medicine, Kanagawa, Japan. | lld:pubmed |
| pubmed-article:1576590 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1576590 | pubmed:publicationType | In Vitro | lld:pubmed |
