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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-4
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pubmed:abstractText |
Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15746913-Animals,
pubmed-meshheading:15746913-Behavior, Animal,
pubmed-meshheading:15746913-Biological Clocks,
pubmed-meshheading:15746913-Cell Count,
pubmed-meshheading:15746913-Chi-Square Distribution,
pubmed-meshheading:15746913-Circadian Rhythm,
pubmed-meshheading:15746913-Culture Techniques,
pubmed-meshheading:15746913-Diagnostic Imaging,
pubmed-meshheading:15746913-Eye Proteins,
pubmed-meshheading:15746913-Functional Laterality,
pubmed-meshheading:15746913-Gene Expression Regulation,
pubmed-meshheading:15746913-Green Fluorescent Proteins,
pubmed-meshheading:15746913-Light,
pubmed-meshheading:15746913-Mice,
pubmed-meshheading:15746913-Mice, Transgenic,
pubmed-meshheading:15746913-Motor Activity,
pubmed-meshheading:15746913-Neurons,
pubmed-meshheading:15746913-Period Circadian Proteins,
pubmed-meshheading:15746913-Suprachiasmatic Nucleus,
pubmed-meshheading:15746913-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Constant light desynchronizes mammalian clock neurons.
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pubmed:affiliation |
Department of Biological Sciences, Vanderbilt University, VU Station B, Box 35-1634, Nashville, Tennessee 37235-1634, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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