|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011164,
umls-concept:C0013227,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0035304,
umls-concept:C0206116,
umls-concept:C0439834,
umls-concept:C0449774,
umls-concept:C0750729,
umls-concept:C1280500,
umls-concept:C1879547
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-5-25
|
|
pubmed:abstractText |
In hereditary retinal degeneration, microglia cells become activated, migrate through the outer nuclear layer (ONL) and accumulate in the subretinal space. Although this inflammatory process is not likely to be responsible for the onset of photoreceptor apoptosis, cytotoxic substances secreted by activated microglia could potentially accelerate and perpetuate the degenerative process. Anti-inflammatory drugs have been shown to modulate the microglia response in neurodegenerative disorders and potentially ameliorate the disease progression in various animal model systems. In this study we wanted to test the impact of the most commonly used anti-inflammatory drugs (acetylsalicylate and prednisolone) on the microglia activation pattern, the rate of caspase-3-dependent photoreceptor apoptosis and the course of the degeneration in the retinal degeneration slow (rds) mouse retina.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisolone,
http://linkedlifedata.com/resource/pubmed/chemical/monocyte-macrophage...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0030-3747
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright (c) 2005 S. Karger AG, Basel.
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
37
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
72-82
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15746562-Animals,
pubmed-meshheading:15746562-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15746562-Antigens, Differentiation,
pubmed-meshheading:15746562-Apoptosis,
pubmed-meshheading:15746562-Aspirin,
pubmed-meshheading:15746562-Caspase 3,
pubmed-meshheading:15746562-Caspases,
pubmed-meshheading:15746562-Cell Count,
pubmed-meshheading:15746562-Cell Movement,
pubmed-meshheading:15746562-Glucocorticoids,
pubmed-meshheading:15746562-Immunoenzyme Techniques,
pubmed-meshheading:15746562-Injections, Intraperitoneal,
pubmed-meshheading:15746562-Mice,
pubmed-meshheading:15746562-Mice, Inbred CBA,
pubmed-meshheading:15746562-Mice, Mutant Strains,
pubmed-meshheading:15746562-Microglia,
pubmed-meshheading:15746562-Microscopy, Confocal,
pubmed-meshheading:15746562-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:15746562-Prednisolone,
pubmed-meshheading:15746562-Retinal Degeneration
|
|
pubmed:articleTitle |
Effect of steroidal and non-steroidal drugs on the microglia activation pattern and the course of degeneration in the retinal degeneration slow mouse.
|
|
pubmed:affiliation |
University Eye Clinic, Inselspital, CH-3010 Bern, Switzerland. gian-marco.sarra@insel.ch
|
|
pubmed:publicationType |
Journal Article
|
