Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1979-10-17
|
| pubmed:abstractText |
A fatal, widespread, polyclonal, B-cell immunoblastic lymphoproliferative disorder developed in three children with combined immunodeficiency shortly after intra-abdominal transplantation of cultured thymus epithelium for immunoreconstitution. All three had surface immunoglobulin-bearing cells (15 to 20 per cent) in the peripheral blood before transplantation and polyclonally elevated immunoglobulins afterward. Abnormal immunoregulation was demonstrated by a lack of concanavalin A-induced suppressor-cell activity in mixed leukocyte culture in all three patients before transplantation and in two afterward. We suggest that the transplant acted as a promoter through immunostimulation or production of promoter factors, and that excessive polyclonal B-cell proliferation resulted because of inadequate immunoregulatory mechanisms. Although this complication occurred in only three of 30 patients with various forms of immunodeficiency treated with cultured thymus, these cases illustrate a potential problem in immunoreconstitution of combined immunodeficiency disorders.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0028-4793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
301
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
565-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:157433-B-Lymphocytes,
pubmed-meshheading:157433-Cell Division,
pubmed-meshheading:157433-Child, Preschool,
pubmed-meshheading:157433-Epithelium,
pubmed-meshheading:157433-Female,
pubmed-meshheading:157433-Humans,
pubmed-meshheading:157433-Immunoblastic Lymphadenopathy,
pubmed-meshheading:157433-Immunoglobulins,
pubmed-meshheading:157433-Immunologic Deficiency Syndromes,
pubmed-meshheading:157433-Infant,
pubmed-meshheading:157433-Lymph Nodes,
pubmed-meshheading:157433-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:157433-Lymphoma,
pubmed-meshheading:157433-Male,
pubmed-meshheading:157433-Organ Culture Techniques,
pubmed-meshheading:157433-Receptors, Antigen, B-Cell,
pubmed-meshheading:157433-T-Lymphocytes,
pubmed-meshheading:157433-Thymus Gland,
pubmed-meshheading:157433-Transplantation, Homologous
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
Fatal lymphoma after transplantation of cultured thymus in children with combined immunodeficiency disease.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|