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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
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pubmed:dateCreated |
2005-3-3
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|
pubmed:abstractText |
Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here a novel class of allosteric inhibitor of NS5B that shows potent affinity for the NS5B enzyme and effective inhibition of subgenomic HCV RNA replication in HUH-7 cells. Inhibitors from this class have promising characteristics for further development as anti-HCV agents.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
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pubmed:issn |
0022-2623
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pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
10
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1314-7
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:15743173-Acetamides,
pubmed-meshheading:15743173-Administration, Oral,
pubmed-meshheading:15743173-Allosteric Regulation,
pubmed-meshheading:15743173-Animals,
pubmed-meshheading:15743173-Biological Availability,
pubmed-meshheading:15743173-Cell Line, Tumor,
pubmed-meshheading:15743173-Hepacivirus,
pubmed-meshheading:15743173-Humans,
pubmed-meshheading:15743173-Indoles,
pubmed-meshheading:15743173-RNA, Viral,
pubmed-meshheading:15743173-RNA Replicase,
pubmed-meshheading:15743173-Rats,
pubmed-meshheading:15743173-Structure-Activity Relationship,
pubmed-meshheading:15743173-Viral Nonstructural Proteins
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.
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|
pubmed:affiliation |
IRBM (Merck Research Laboratories Rome), Via Pontina km 30,600, 00040 Pomezia, Rome, Italy. Steven_Harper@merck.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
