|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0022660,
umls-concept:C0033684,
umls-concept:C0086418,
umls-concept:C0384826,
umls-concept:C0525037,
umls-concept:C0591833,
umls-concept:C0936012,
umls-concept:C1515655,
umls-concept:C1533691,
umls-concept:C1704675,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1705280,
umls-concept:C2827404
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|
pubmed:issue |
15
|
|
pubmed:dateCreated |
2005-4-7
|
|
pubmed:abstractText |
Both human and murine ARF proteins have been recently reported to impair rRNA maturation and ribosomes biogenesis through a p53-independent pathway. A specific interaction has been established between 5.8S rRNA and the murine p19ARF specie. We report here, by use of both in vitro and ChIP-RNA assays, the absence of any interaction between the human p14ARF and the homologous 5.8S rRNA. Our data are not consistent with the involvement of a 5.8S-p14ARF complex in ribosome biogenesis in man. Rather they suggest that the human protein does not require such an interaction to achieve a similar function. This result is a new argument in favour of functional differences between human and murine ARF proteins.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0950-9232
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
7
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2580-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
In vitro and in vivo analysis of the interaction between 5.8S rRNA and ARF protein reveal a new difference between murine p19ARF and human p14ARF.
|
|
pubmed:affiliation |
EA 3805, Laboratoire d'Oncologie Moléculaire, Pôle Biologie-Santé, 40 avenue du Recteur Pineau, 86022 Poitiers Cedex, France.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
