Linked Life Data

15723969

Source:http://linkedlifedata.com/resource/pubmed/id/15723969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-3-25
pubmed:abstractText
Structural alterations of subcutaneous small resistance arteries are associated with a worse clinical prognosis in hypertension and noninsulin-dependent diabetes mellitus (NIDDM). However, no data are presently available about the effects of antihypertensive therapy on vascular structure in hypertensive patients with NIDDM. Therefore, we have investigated the effect of an angiotensin-converting enzyme inhibitor, enalapril, and a highly selective angiotensin receptor blocker, candesartan cilexetil, on indices of subcutaneous small resistance artery structure in 15 patients with mild hypertension and NIDDM. Eight patients were treated with candesartan (8 to 16 mg per day) and 7 with enalapril (10 to 20 mg per day) for 1 year. Each patient underwent a biopsy of the subcutaneous fat from the gluteal region at baseline and after 1 year of treatment. Small arteries were dissected and mounted on a micromyograph and the media-to-internal lumen ratio was evaluated; moreover, endothelium-dependent vasodilation to acetylcholine was assessed. A similar blood pressure-lowering effect and a similar reduction of the media-to-lumen ratio of small arteries was observed with the 2 drugs. Vascular collagen content was reduced and metalloproteinase-9 was increased by candesartan, but not by enalapril. Changes of circulating indices of collagen turnover and circulating matrix metalloproteinase paralleled those of vascular collagen. The 2 drugs equally improved endothelial function. In conclusion, antihypertensive treatment with drugs that inhibit the renin-angiotensin-aldosterone system activity is able to correct, at least in part, alterations in small resistance artery structure in hypertensive patients with NIDDM. Candesartan may be more effective than enalapril in reducing collagen content in the vasculature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
659-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15723969-Adult, pubmed-meshheading:15723969-Aged, pubmed-meshheading:15723969-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:15723969-Angiotensin-Converting Enzyme Inhibitors, pubmed-meshheading:15723969-Arteries, pubmed-meshheading:15723969-Benzimidazoles, pubmed-meshheading:15723969-Biphenyl Compounds, pubmed-meshheading:15723969-Diabetes Mellitus, Type 2, pubmed-meshheading:15723969-Echocardiography, pubmed-meshheading:15723969-Enalapril, pubmed-meshheading:15723969-Endothelium, Vascular, pubmed-meshheading:15723969-Female, pubmed-meshheading:15723969-Humans, pubmed-meshheading:15723969-Hypertension, pubmed-meshheading:15723969-Male, pubmed-meshheading:15723969-Matrix Metalloproteinase 9, pubmed-meshheading:15723969-Middle Aged, pubmed-meshheading:15723969-Subcutaneous Tissue, pubmed-meshheading:15723969-Tetrazoles
pubmed:year
2005
pubmed:articleTitle
Effect of treatment with candesartan or enalapril on subcutaneous small artery structure in hypertensive patients with noninsulin-dependent diabetes mellitus.
pubmed:affiliation
Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy. rizzoni@med.unibs.it
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial