Source:http://linkedlifedata.com/resource/pubmed/id/15723005
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2005-2-21
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| pubmed:abstractText |
Myopia is a common complex eye disorder, with implications for blindness due to increased risk of retinal detachment, chorioretinal degeneration, premature cataracts, and glaucoma. A genomic interval of 2.2 centiMorgans (cM) was defined on chromosome band 18p11.31 using 7 families diagnosed with autosomal dominant high myopia and was designated the MYP2 locus. To characterize this region, we analyzed 9 known candidate genes localized to within the 2.2 cM interval by direct sequencing.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1090-0535
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
2
|
| pubmed:volume |
11
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
97-110
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:15723005-Chromosomes, Human, Pair 18,
pubmed-meshheading:15723005-DNA Mutational Analysis,
pubmed-meshheading:15723005-Gene Expression Profiling,
pubmed-meshheading:15723005-Genes, Dominant,
pubmed-meshheading:15723005-Genetic Testing,
pubmed-meshheading:15723005-Genome, Human,
pubmed-meshheading:15723005-Humans,
pubmed-meshheading:15723005-Myopia, Degenerative,
pubmed-meshheading:15723005-Polymorphism, Genetic,
pubmed-meshheading:15723005-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15723005-Sequence Analysis, DNA
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| pubmed:year |
2005
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| pubmed:articleTitle |
Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes.
|
| pubmed:affiliation |
Division of Ophthalmology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|