| pubmed-article:15710476 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C1705079 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C0004112 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C0108685 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C1337092 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C1522558 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C0961954 | lld:lifeskim |
| pubmed-article:15710476 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:15710476 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:15710476 | pubmed:dateCreated | 2005-2-15 | lld:pubmed |
| pubmed-article:15710476 | pubmed:abstractText | The chemoattractant protein 1 (MCP-1) is one of the most potent monocyte chemoattractants whose level is elevated during the course of AIDS dementia. Earlier studies showed that HIV-1 Tat protein is able to induce transcription of the MCP-1 promoter in astrocytic cells. Furthermore, the TGFbeta-1 signaling pathway through its regulatory proteins, Smads, modulates Tat activation of MCP-1. Here, we demonstrate that C/EBPbeta, whose activity is enhanced by a variety of cytokines during the course of viral infection, can stimulate basal- and Tat-mediated transcription of MCP-1 in human astrocytic cells. Results using promoter deletion mutants suggested the importance of multiple C/EBPbeta binding sites scattered within -200 to +1 of the MCP-1 promoter in the observed activity. Results from DNA binding studies have shown that the interaction of C/EBPbeta with its DNA motif is diminished by the C/EBPbeta homologous protein, CHOP, which possesses the ability to suppress the stimulatory effect of C/EBPbeta on MCP-1 transcription. Tat, which possesses the ability to interact with C/EBPbeta, alleviates the negative effect of CHOP and restores C/EBPbeta interaction with the DNA. Furthermore, Smad3 and its C-terminal regulatory motif, MH2, interact with C/EBPbeta and modulate its DNA binding and transcriptional activity on the MCP-1 promoter. Our results show that the physical and functional interactions of C/EBPbeta and Tat are severely affected by the presence of Smad3 and MH2. Altogether, these observations identify C/EBPbeta as a new partner for Tat in stimulating MCP-1 transcription in astrocytes and suggest that the delicate balance among the downstream regulatory proteins of several cytokines and immunomodulators can dictate the level of expression of chemoattractants, including MCP-1. Hence, inappropriate expression and function of regulatory proteins such as C/EBPbeta and Smads by Tat may induce MCP-1 production in astrocytes and contribute to the neuropathogenesis of AIDS through stimulation of inflammation in the CNS. | lld:pubmed |
| pubmed-article:15710476 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15710476 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15710476 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15710476 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15710476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15710476 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15710476 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15710476 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:15710476 | pubmed:author | pubmed-author:RappaportJayJ | lld:pubmed |
| pubmed-article:15710476 | pubmed:author | pubmed-author:AbrahamSelvaj... | lld:pubmed |
| pubmed-article:15710476 | pubmed:author | pubmed-author:KhaliliKamelK | lld:pubmed |
| pubmed-article:15710476 | pubmed:author | pubmed-author:AminiShohrehS | lld:pubmed |
| pubmed-article:15710476 | pubmed:author | pubmed-author:SawayaBassel... | lld:pubmed |
| pubmed-article:15710476 | pubmed:author | pubmed-author:SweetThersaT | lld:pubmed |
| pubmed-article:15710476 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15710476 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:15710476 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15710476 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15710476 | pubmed:pagination | 219-27 | lld:pubmed |
| pubmed-article:15710476 | pubmed:dateRevised | 2010-8-13 | lld:pubmed |
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| pubmed-article:15710476 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15710476 | pubmed:articleTitle | Cooperative interaction of C/EBP beta and Tat modulates MCP-1 gene transcription in astrocytes. | lld:pubmed |
| pubmed-article:15710476 | pubmed:affiliation | Center for Neurovirology and Cancer Biology, Temple University, 1900 North 12th Street, 015-96, Room 203, Philadelphia, PA 19122, USA. | lld:pubmed |
| pubmed-article:15710476 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15710476 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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