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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2 Pt 1
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pubmed:dateCreated |
2005-2-9
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pubmed:abstractText |
Matrix metalloproteinase (MMP) belongs to a large group of proteases capable of breaking essentially all components of the extracellular matrix. They are implicated in all steps of tumorogenesis, cancer invasion, and metastasis. Among them, metalloproteinase type 1 (MMP-1) is implicated in tumor invasion and metastasis in different types of cancers including colorectal cancer in which its expression was correlated with poor prognosis. A polymorphism in the promoter region of the MMP-1 gene leads to a variation of its level of transcription.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
594-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15701845-Adult,
pubmed-meshheading:15701845-Aged,
pubmed-meshheading:15701845-Aged, 80 and over,
pubmed-meshheading:15701845-Alleles,
pubmed-meshheading:15701845-Blotting, Western,
pubmed-meshheading:15701845-Colorectal Neoplasms,
pubmed-meshheading:15701845-Female,
pubmed-meshheading:15701845-Genotype,
pubmed-meshheading:15701845-Humans,
pubmed-meshheading:15701845-Lymphatic Metastasis,
pubmed-meshheading:15701845-Male,
pubmed-meshheading:15701845-Matrix Metalloproteinase 1,
pubmed-meshheading:15701845-Matrix Metalloproteinase 3,
pubmed-meshheading:15701845-Middle Aged,
pubmed-meshheading:15701845-Neoplasm Invasiveness,
pubmed-meshheading:15701845-Neoplasm Staging,
pubmed-meshheading:15701845-Polymorphism, Genetic,
pubmed-meshheading:15701845-Prognosis,
pubmed-meshheading:15701845-Promoter Regions, Genetic,
pubmed-meshheading:15701845-RNA, Messenger,
pubmed-meshheading:15701845-RNA, Neoplasm,
pubmed-meshheading:15701845-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15701845-Survival Rate,
pubmed-meshheading:15701845-Tumor Markers, Biological
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pubmed:year |
2005
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pubmed:articleTitle |
Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.
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pubmed:affiliation |
INSERM U490, Laboratoire de toxicologie Moléculaire, 45 rue des Saintes Pères, 75006 Paris, France.
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pubmed:publicationType |
Journal Article
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