| pubmed-article:1569329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0022567 | lld:lifeskim |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0221928 | lld:lifeskim |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0282547 | lld:lifeskim |
| pubmed-article:1569329 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1569329 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1569329 | pubmed:dateCreated | 1992-5-28 | lld:pubmed |
| pubmed-article:1569329 | pubmed:abstractText | A large synthesis of human IL-6 was demonstrated in co-cultures of human keratinocytes on post-mitotic human dermal fibroblast (HDF) feeder layers. Immunoreactive IL-1 beta could be detected in the co-cultures and the addition of rabbit anti-IL-1 beta antibodies to the co-cultures considerably reduced the IL-6 synthesis, suggesting that it was induced by endogenous IL-1 beta. Addition of saturating concentrations of IL-1 beta to HDF feeder layers as well as to subcultures of keratinocytes induced in both similar but moderate IL-6 production. Conditioned medium from keratinocyte cultures induced IL-6 secretion in HDF feeder cells, whereas the conditioned medium from HDF feeder layers led to only minimal increase of keratinocyte IL-6 production. The co-cultures of keratinocytes on HDF feeder layers produced much larger amounts of IL-6 than the sum of the IL-6 produced by the feeder cell and keratinocyte cultures after the addition of IL-1 beta. The co-cultures of keratinocytes with HDF feeder layers separated by a permeable membrane in a two-chamber system produced significantly lower amounts of IL-6 than the unseparated co-cultures. These findings indicate that a direct cell contact between keratinocytes and feeder cells is involved in the overproportioned increase of IL-6 production and secretion into the medium. | lld:pubmed |
| pubmed-article:1569329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1569329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1569329 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1569329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1569329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1569329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1569329 | pubmed:month | May | lld:pubmed |
| pubmed-article:1569329 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:1569329 | pubmed:author | pubmed-author:WiesmannUU | lld:pubmed |
| pubmed-article:1569329 | pubmed:author | pubmed-author:BraathenL RLR | lld:pubmed |
| pubmed-article:1569329 | pubmed:author | pubmed-author:PèreCC | lld:pubmed |
| pubmed-article:1569329 | pubmed:author | pubmed-author:HunzikerTT | lld:pubmed |
| pubmed-article:1569329 | pubmed:author | pubmed-author:WaeltiE RER | lld:pubmed |
| pubmed-article:1569329 | pubmed:author | pubmed-author:LimatAA | lld:pubmed |
| pubmed-article:1569329 | pubmed:author | pubmed-author:InaebnitS PSP | lld:pubmed |
| pubmed-article:1569329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1569329 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:1569329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1569329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1569329 | pubmed:pagination | 805-8 | lld:pubmed |
| pubmed-article:1569329 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:meshHeading | pubmed-meshheading:1569329-... | lld:pubmed |
| pubmed-article:1569329 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1569329 | pubmed:articleTitle | Co-culture of human keratinocytes on post-mitotic human dermal fibroblast feeder cells: production of large amounts of interleukin 6. | lld:pubmed |
| pubmed-article:1569329 | pubmed:affiliation | Department of Pathology, University of Berne, Switzerland. | lld:pubmed |
| pubmed-article:1569329 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1569329 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1569329 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1569329 | lld:pubmed |
