Source:http://linkedlifedata.com/resource/pubmed/id/15691663
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-2-4
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pubmed:abstractText |
(123)I-Iodo-alpha-methyltyrosine (IMT) transport into lymphomas has not been fully characterized. In rat Nb2-11C and Nb2-Sp lymphoma cell lines, linear uptake of (123)I-IMT occurred rapidly within 5-10 min. Eadie-Hoftee plots of (123)I-IMT uptake gave apparent Km's of 8.34+/-1.17 and 9.64+/-1.05 microM for Nb2-11C and Nb2-Sp cells, respectively, and involved the L and B(0,+) systems. In lymphoma-bearing rats, injected (123)I-IMT accumulated rapidly in the primary tumors but gave a low tumor-to-background ratio of 2:1. (123)I-IMT was transported rapidly into lymphoma cells both in vitro and in vivo, but low target-to-nontarget ratio may not make (123)I-IMT practical for scanning in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0969-8051
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15691663-Animals,
pubmed-meshheading:15691663-Biological Transport, Active,
pubmed-meshheading:15691663-Cell Line, Tumor,
pubmed-meshheading:15691663-Kidney,
pubmed-meshheading:15691663-Lymphoma,
pubmed-meshheading:15691663-Male,
pubmed-meshheading:15691663-Metabolic Clearance Rate,
pubmed-meshheading:15691663-Methyltyrosines,
pubmed-meshheading:15691663-Organ Specificity,
pubmed-meshheading:15691663-Radiopharmaceuticals,
pubmed-meshheading:15691663-Rats,
pubmed-meshheading:15691663-Tissue Distribution
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pubmed:year |
2005
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pubmed:articleTitle |
Characterization of (123)I-iodo-alpha-methyltyrosine transport in rat lymphoma cells.
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pubmed:affiliation |
Department of Diagnostic Imaging, QEII Health Sciences Centre, 1278 Tower Road, VG Site, Halifax, Nova Scotia, B3H 2Y9, Canada. gmatte@dal.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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