Linked Life Data

1568867

Source:http://linkedlifedata.com/resource/pubmed/id/1568867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-5-22
pubmed:abstractText
Pulmonary hypersensitivity granulomas were induced in immunized mice by the intratracheal injection of antigen-coupled agarose beads. Foreign body lung granulomas were induced in mice by the intratracheal injection of dextran beads. Both lesions developed within 1 day, reached peak intensity within 3 days, and gradually declined in size thereafter. Hypersensitivity granulomas were much larger than foreign body lesions. The lung extracts prepared from mice with hypersensitivity lung granulomas, but not foreign body lesions, contained high levels of superoxide dismutase (SOD) and thiobarbiturate-reactive substances including lipid peroxides. SOD activity and levels of thiobarbiturate-reactive substances in the extracts correlated with sizes of hypersensitive lesions. Hypersensitivity granulomas, but not foreign body lesions, were inhibited by the administration of recombinant human SOD (rh-SOD). Thiobarbiturate-reactive substances were decreased in the lung extracts of mice bearing hypersensitivity granulomas injected with rh-SOD. These results suggest that reactive oxygen intermediates such as superoxide anion may play an important role in the development of hypersensitivity granulomas and that rh-SOD is capable of inhibiting the lesions by its antioxidant action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0162-3109
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-13
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Suppression of pulmonary hypersensitivity granulomas in mice by superoxide dismutase.
pubmed:affiliation
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't