Linked Life Data

15687711

Source:http://linkedlifedata.com/resource/pubmed/id/15687711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-2-2
pubmed:abstractText
In spite of the demonstrated coexistence of tumor-associated rejection antigens expressed by breast tumors along with T cells that are capable of recognize them, breast cancers arises in immunocompetent hosts, outmaneuver immune recognition and ultimately progress to widely disseminated disease. In recent years, several explanations have been proposed to account for the inability of the immune system to recognize and reject antigenic breast tumors. Among them, the immune tolerance mechanisms have gained particular attention. Here, we discuss the increasing evidence pointing to tolerance towards tumor antigens as an important explanation for the failure of the immune system to reject breast tumors. A better understanding of the cellular and molecular mechanisms involved in breast tumor-induced antigen-specific T-cell tolerance may lead to approaches to effectively harness the immune system against this malignancy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0888-6008
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-103
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Immune tolerance in breast cancer.
pubmed:affiliation
Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida, Tampa, FL 33612-9497, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review