15681184

Source:http://linkedlifedata.com/resource/pubmed/id/15681184

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007634, umls-concept:C0037107, umls-concept:C0184511, umls-concept:C0205148, umls-concept:C0392747, umls-concept:C0596177, umls-concept:C1554963
pubmed:issue	9
pubmed:dateCreated	2005-1-31
pubmed:abstractText	Clean silicon and gold-patterned silicon platforms were modified with methoxy-polyethylene glycol (M-PEG silane) via a self-assembly technique, which significantly improved their plasma protein resistance capability and cell patterning selectivity. Fibrinogen and IgG were used as model plasma proteins to study the efficacy of PEG layers in resisting protein adsorption. Selective cell patterning on the gold regions of a gold-patterned silicon substrate and tissue compatibility were studied with macrophage and fibroblast cells. The research also revealed how the presence of gold electrodes on a silicon substrate would influence the cell patterning selectivity. Our experimental results showed that the PEG-modified silicon surfaces had a high resistivity to protein and cell attachment and that the PEG-modified gold-patterned silicon surfaces nearly completely eliminated the protein adsorption and cell attachment on silicon. This study provides a new approach to developing biocompatible surfaces for silicon-based BioMEMS devices, particularly for biosensors where a metal-insulator format must be enforced.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9001289
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials, http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen, http://linkedlifedata.com/resource/pubmed/chemical/Gold, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G, http://linkedlifedata.com/resource/pubmed/chemical/Silanes, http://linkedlifedata.com/resource/pubmed/chemical/Silicon
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0956-5663
pubmed:author	pubmed-author:LanSheenyS, pubmed-author:VeisehMandanaM, pubmed-author:ZhangMiqinM
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1697-708
pubmed:dateRevised	2009-7-14
pubmed:meshHeading	pubmed-meshheading:15681184-Adsorption, pubmed-meshheading:15681184-Animals, pubmed-meshheading:15681184-Biocompatible Materials, pubmed-meshheading:15681184-Biosensing Techniques, pubmed-meshheading:15681184-Cell Adhesion, pubmed-meshheading:15681184-Cell Culture Techniques, pubmed-meshheading:15681184-Cell Line, pubmed-meshheading:15681184-Cell Survival, pubmed-meshheading:15681184-Fibrinogen, pubmed-meshheading:15681184-Fibroblasts, pubmed-meshheading:15681184-Gold, pubmed-meshheading:15681184-Immunoglobulin G, pubmed-meshheading:15681184-Macrophages, pubmed-meshheading:15681184-Materials Testing, pubmed-meshheading:15681184-Mice, pubmed-meshheading:15681184-Protein Binding, pubmed-meshheading:15681184-Silanes, pubmed-meshheading:15681184-Silicon, pubmed-meshheading:15681184-Surface Properties, pubmed-meshheading:15681184-Tissue Engineering
pubmed:year	2005
pubmed:articleTitle	Surface modification of silicon and gold-patterned silicon surfaces for improved biocompatibility and cell patterning selectivity.
pubmed:affiliation	Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Evaluation Studies