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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-2-7
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pubmed:abstractText |
New derivatives of 4-N-benzylamino-4-hetarylbut-1-ene containing a pyridyl nucleus were synthesized from benzylamines and pyridine aldehydes. N-oxide derivatives were obtained from these homoallylamines. Study of the antiparasitic properties of obtained pyridine derivatives as well as of four related benzazepines previously described, was carried out using cytotoxicity assays against Trichomonas vaginalis and epimastigote form of Trypanosoma cruzi protozoa. Compounds showing activity against epimastigote T. cruzi were tested against the amastigote form; unspecific cytotoxicity against macrophages was also studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0365-6233
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pubmed:author |
pubmed-author:Amaro-LuisJuanJ,
pubmed-author:BahsasAlíA,
pubmed-author:BarrioAlicia GómezAG,
pubmed-author:CastroJuliette RiveroJR,
pubmed-author:KouznetsovVladimir VVV,
pubmed-author:MartínezJairo RenéJR,
pubmed-author:OchoaCarmenC,
pubmed-author:PereiraDavid MonteroDM,
pubmed-author:PortilloCarlos FernándezCF,
pubmed-author:PuentesCristian OchoaCO,
pubmed-author:RuizJuan J NogalJJ,
pubmed-author:SerranoSusana MuelasSM,
pubmed-author:StashenkoElena EEE
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pubmed:issnType |
Print
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pubmed:volume |
338
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
32-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis and antiparasitic properties of new 4-N-benzylamino-4-hetarylbut-1-enes.
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pubmed:affiliation |
Laboratory of Fine Organic Synthesis, Research Center for Biomolecules, School of Chemistry, Industrial University of Santander, AA 678, Bucaramanga, Colombia. kouznet@uis.edu.co
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
