| pubmed-article:15673723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15673723 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:15673723 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:15673723 | lifeskim:mentions | umls-concept:C0812405 | lld:lifeskim |
| pubmed-article:15673723 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15673723 | pubmed:dateCreated | 2005-1-27 | lld:pubmed |
| pubmed-article:15673723 | pubmed:abstractText | The emergence and spread of drug-resistant Plasmodium falciparum continue to pose problems in malaria chemotherapy. Therefore, it is necessary to identify new antimalarial drugs and therapeutic strategies. In the present study, the activity of a heat-treated form of amphotericin B (HT-AMB) against P. falciparum was evaluated. The efficacy and toxicity of HT-AMB were also compared with those of the standard formulation (AMB). HT-AMB showed significant activity against a chloroquine-resistant strain (strain K-1) and a chloroquine-susceptible strain (strain FCR-3) in vitro. The 50% inhibitory concentrations of HT-AMB were 0.32 +/- 0.03 mug/ml for strain K-1 and 0.33 +/- 0.03 mug/ml for strain FCR-3. In the presence of 1.0 mug of HT-AMB per ml, only pyknotic parasites were observed after 24 h of incubation of early trophozoites (ring forms). However, when late trophozoites and schizonts were cultured with 1.0 mug of HT-AMB per ml, those forms multiplied to ring forms but the number of infected erythrocytes did not increase. These results indicate that HT-AMB possesses potent antiplasmodial activity and that the drug is more effective against the ring-form stage than against the late trophozoite and schizont stages. HT-AMB was observed to have little cytotoxic effect against a human liver cell line (Chang liver cells). In conclusion, the results suggest that HT-AMB has promising properties and merits further in vivo investigations as a treatment for falciparum malaria. | lld:pubmed |
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| pubmed-article:15673723 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15673723 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15673723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15673723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15673723 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15673723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15673723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15673723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15673723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15673723 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:15673723 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:15673723 | pubmed:author | pubmed-author:SuzukiMamoruM | lld:pubmed |
| pubmed-article:15673723 | pubmed:author | pubmed-author:HatabuToshimi... | lld:pubmed |
| pubmed-article:15673723 | pubmed:author | pubmed-author:KanoShigeyuki... | lld:pubmed |
| pubmed-article:15673723 | pubmed:author | pubmed-author:TakadaTsuyosh... | lld:pubmed |
| pubmed-article:15673723 | pubmed:author | pubmed-author:TaguchiNaoN | lld:pubmed |
| pubmed-article:15673723 | pubmed:author | pubmed-author:SatoKumikoK | lld:pubmed |
| pubmed-article:15673723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15673723 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:15673723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15673723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15673723 | pubmed:pagination | 493-6 | lld:pubmed |
| pubmed-article:15673723 | pubmed:dateRevised | 2010-9-20 | lld:pubmed |
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| pubmed-article:15673723 | pubmed:meshHeading | pubmed-meshheading:15673723... | lld:pubmed |
| pubmed-article:15673723 | pubmed:meshHeading | pubmed-meshheading:15673723... | lld:pubmed |
| pubmed-article:15673723 | pubmed:meshHeading | pubmed-meshheading:15673723... | lld:pubmed |
| pubmed-article:15673723 | pubmed:meshHeading | pubmed-meshheading:15673723... | lld:pubmed |
| pubmed-article:15673723 | pubmed:meshHeading | pubmed-meshheading:15673723... | lld:pubmed |
| pubmed-article:15673723 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15673723 | pubmed:articleTitle | Potent plasmodicidal activity of a heat-induced reformulation of deoxycholate-amphotericin B (Fungizone) against Plasmodium falciparum. | lld:pubmed |
| pubmed-article:15673723 | pubmed:affiliation | Gunma University School of Health Sciences, 3-39-15 Showa-machi, Maebashi 371-8514, Japan. hatabu@health.gunma-u.ac.jp | lld:pubmed |
| pubmed-article:15673723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15673723 | pubmed:publicationType | Comparative Study | lld:pubmed |
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