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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2005-1-27
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pubmed:abstractText |
The emergence and spread of drug-resistant Plasmodium falciparum continue to pose problems in malaria chemotherapy. Therefore, it is necessary to identify new antimalarial drugs and therapeutic strategies. In the present study, the activity of a heat-treated form of amphotericin B (HT-AMB) against P. falciparum was evaluated. The efficacy and toxicity of HT-AMB were also compared with those of the standard formulation (AMB). HT-AMB showed significant activity against a chloroquine-resistant strain (strain K-1) and a chloroquine-susceptible strain (strain FCR-3) in vitro. The 50% inhibitory concentrations of HT-AMB were 0.32 +/- 0.03 mug/ml for strain K-1 and 0.33 +/- 0.03 mug/ml for strain FCR-3. In the presence of 1.0 mug of HT-AMB per ml, only pyknotic parasites were observed after 24 h of incubation of early trophozoites (ring forms). However, when late trophozoites and schizonts were cultured with 1.0 mug of HT-AMB per ml, those forms multiplied to ring forms but the number of infected erythrocytes did not increase. These results indicate that HT-AMB possesses potent antiplasmodial activity and that the drug is more effective against the ring-form stage than against the late trophozoite and schizont stages. HT-AMB was observed to have little cytotoxic effect against a human liver cell line (Chang liver cells). In conclusion, the results suggest that HT-AMB has promising properties and merits further in vivo investigations as a treatment for falciparum malaria.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-10052902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-10228089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-10615892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-10761728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-11284719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-11408223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-11937421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-14507696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-15013789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-2313133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-3251381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-5116171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-7319979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-781840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-8363618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-8994768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-9371331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15673723-9517951
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-6
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pubmed:dateRevised |
2010-9-20
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pubmed:meshHeading |
pubmed-meshheading:15673723-Amphotericin B,
pubmed-meshheading:15673723-Animals,
pubmed-meshheading:15673723-Antifungal Agents,
pubmed-meshheading:15673723-Antimalarials,
pubmed-meshheading:15673723-Cell Line,
pubmed-meshheading:15673723-Cell Survival,
pubmed-meshheading:15673723-Chemistry, Pharmaceutical,
pubmed-meshheading:15673723-Hemolysis,
pubmed-meshheading:15673723-Hepatocytes,
pubmed-meshheading:15673723-Hot Temperature,
pubmed-meshheading:15673723-Humans,
pubmed-meshheading:15673723-Plasmodium falciparum
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pubmed:year |
2005
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pubmed:articleTitle |
Potent plasmodicidal activity of a heat-induced reformulation of deoxycholate-amphotericin B (Fungizone) against Plasmodium falciparum.
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pubmed:affiliation |
Gunma University School of Health Sciences, 3-39-15 Showa-machi, Maebashi 371-8514, Japan. hatabu@health.gunma-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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