|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2005-1-26
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|
pubmed:abstractText |
Relationships between toxicity and pharmacokinetics have been shown for cyclophosphamide, thiotepa, and carboplatin (CTC) in high-dose chemotherapy. We prospectively evaluated whether variability in exposure to CTC and their activated metabolites can be decreased with pharmacokinetically guided dose administration and evaluated its clinical effect.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
1
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
273-83
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:15671556-Adolescent,
pubmed-meshheading:15671556-Adult,
pubmed-meshheading:15671556-Algorithms,
pubmed-meshheading:15671556-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15671556-Area Under Curve,
pubmed-meshheading:15671556-Bayes Theorem,
pubmed-meshheading:15671556-Breast Neoplasms,
pubmed-meshheading:15671556-Carboplatin,
pubmed-meshheading:15671556-Cyclophosphamide,
pubmed-meshheading:15671556-Drug Administration Schedule,
pubmed-meshheading:15671556-Drug Monitoring,
pubmed-meshheading:15671556-Female,
pubmed-meshheading:15671556-Humans,
pubmed-meshheading:15671556-Male,
pubmed-meshheading:15671556-Middle Aged,
pubmed-meshheading:15671556-Neoplasms,
pubmed-meshheading:15671556-Neoplasms, Germ Cell and Embryonal,
pubmed-meshheading:15671556-Ovarian Neoplasms,
pubmed-meshheading:15671556-Thiotepa,
pubmed-meshheading:15671556-Time Factors,
pubmed-meshheading:15671556-Treatment Outcome
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
Accuracy, feasibility, and clinical impact of prospective Bayesian pharmacokinetically guided dosing of cyclophosphamide, thiotepa, and carboplatin in high-dose chemotherapy.
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|
pubmed:affiliation |
Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands. apmil@slz.nl
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|
