Source:http://linkedlifedata.com/resource/pubmed/id/15664865
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-1-24
|
| pubmed:abstractText |
A series of 1-aza-9-oxafluorenes with functionally varied 3-substituents have been prepared from N-phenoxycarbonyl-4-phenyl-1,4-dihydropyridines and p-benzoquinone and biologically evaluated as inhibitors of various cyclin-dependant kinases. The absence of a 3-hydrogen bond acceptor function leads to a complete loss of inhibitory activity. Differing hydrogen bond acceptor functions surprisingly cause significant shifts in the selectivity of inhibition profiles.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
823-5
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:15664865-Binding Sites,
pubmed-meshheading:15664865-Cyclin-Dependent Kinases,
pubmed-meshheading:15664865-Enzyme Inhibitors,
pubmed-meshheading:15664865-Fluorenes,
pubmed-meshheading:15664865-Humans,
pubmed-meshheading:15664865-Hydrogen Bonding,
pubmed-meshheading:15664865-Inhibitory Concentration 50,
pubmed-meshheading:15664865-Structure-Activity Relationship
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.
|
| pubmed:affiliation |
Institute of Pharmaceutical Chemistry, Department of Pharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|