Source:http://linkedlifedata.com/resource/pubmed/id/15664847
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2005-1-24
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pubmed:abstractText |
We report the synthesis of and binding to the two subtypes of mouse thyrotropin-releasing hormone (TRH) receptors, TRH-R1 and TRH-R2, of several 1-(phenyl)isoquinoline carboxamide analogues. These analogues showed a degree of selectivity for binding at TRH-R2. These are the first ligands reported that show selective binding to these receptors.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15664847-Amides,
pubmed-meshheading:15664847-Animals,
pubmed-meshheading:15664847-Binding, Competitive,
pubmed-meshheading:15664847-Isoquinolines,
pubmed-meshheading:15664847-Ligands,
pubmed-meshheading:15664847-Mice,
pubmed-meshheading:15664847-Radioligand Assay,
pubmed-meshheading:15664847-Receptors, Thyrotropin-Releasing Hormone,
pubmed-meshheading:15664847-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors.
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pubmed:affiliation |
Chemical Biology Core Facility, National Institute of Diabetes and Digestive and Kidney Disorders, National Institutes of Health, Bethesda, MD 20892-1818, USA.
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pubmed:publicationType |
Journal Article
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