Linked Life Data

15653200

Source:http://linkedlifedata.com/resource/pubmed/id/15653200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-17
pubmed:abstractText
Objective: It is known that the placenta acts as an immunological barrier between the mother and fetal "graft" allowing two antigenically different organisms to tolerate one another. Preeclampsia may be considered as a fetal rejection consequent to severe damage at placental endothelial and syncytiotrophoblast level. In order to verify this placental barrier damage we undertook the present study by electron microscopy. Study design: 14 placentae from preeclaptic women, and the same number of placentae from healthy controls were examined. Results: The results showed that endothelial cells from preeclamptic placentae express various and severe alterations, consisting of swollen and bulbous cytoplasm, degenerated inter-endothelial junctions with consequent crossing of fetal blood cells outside the vessels. Conclusions: These lesions could be the ultrastructural evidence of the placental barrier breakage leading to rejective reaction we presumed to be basis of preeclampsia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0301-2115
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
182-9
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Placental barrier breakage in preeclampsia: ultrastructural evidence.
pubmed:affiliation
Department of Reproductive Medicine and Child Development, University of Pisa, S. Chiara Hospital, Via Roma 55, Pisa 56100, Italy. delucabrunori@hotmail.com
pubmed:publicationType
Journal Article