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| pubmed-article:15644410 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:15644410 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
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| pubmed-article:15644410 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15644410 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:15644410 | pubmed:dateCreated | 2005-4-21 | lld:pubmed |
| pubmed-article:15644410 | pubmed:abstractText | Exposure of endothelial cells to recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced a modest (2-fold) increase of HL-60 cell adhesion as compared to TNF-alpha (40-fold) or interleukin 1beta (IL-1beta; 20-fold). However, pretreatment of endothelial cultures with TRAIL determined a significant reduction of the proadhesive activity induced by both TNF-alpha and IL-1beta. Unexpectedly, the antiadhesive activity of TRAIL was not due to interference with the nuclear factor kappaB (NF-kappaB)-mediated up-regulation of surface intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin adhesion molecules in response to inflammatory cytokines. In searching for the molecular mechanism underlying this biologic activity of TRAIL, a cDNA microarray analysis was performed. TRAIL pretreatment variably down-modulated the mRNA steady-state levels of several TNF-alpha-induced chemokines, and, in particular, it abrogated the TNF-alpha-mediated up-regulation of CCL8 and CXCL10. Of note, the addition of optimal concentrations of recombinant CCL8 plus CXCL10 to endothelial cultures completely restored the proadhesive activity of TNF-alpha. Moreover, experiments performed with agonistic anti-TRAIL receptor antibodies demonstrated that both TRAIL-R1 and TRAIL-R2 contributed, although at different levels, to TRAIL-induced chemokine modulation. Taken together, our data suggest that TRAIL might play an important role in modulating leukocyte/endothelial cell adhesion by selectively down-regulating CCL8 and CXCL10 chemokines. | lld:pubmed |
| pubmed-article:15644410 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15644410 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15644410 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15644410 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15644410 | pubmed:month | May | lld:pubmed |
| pubmed-article:15644410 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:15644410 | pubmed:author | pubmed-author:SecchieroPaol... | lld:pubmed |
| pubmed-article:15644410 | pubmed:author | pubmed-author:ZauliGiorgioG | lld:pubmed |
| pubmed-article:15644410 | pubmed:author | pubmed-author:GonelliAriann... | lld:pubmed |
| pubmed-article:15644410 | pubmed:author | pubmed-author:CoralliniFede... | lld:pubmed |
| pubmed-article:15644410 | pubmed:author | pubmed-author:BarbarottoEli... | lld:pubmed |
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| pubmed-article:15644410 | pubmed:issnType | Print | lld:pubmed |
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| pubmed-article:15644410 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:15644410 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15644410 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15644410 | pubmed:pagination | 3413-9 | lld:pubmed |
| pubmed-article:15644410 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15644410 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15644410 | pubmed:articleTitle | TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release. | lld:pubmed |
| pubmed-article:15644410 | pubmed:affiliation | Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy. secchier@mail.umbi.umd.edu | lld:pubmed |
| pubmed-article:15644410 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15644410 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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