Linked Life Data

15644271

Source:http://linkedlifedata.com/resource/pubmed/id/15644271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-12
pubmed:abstractText
This study was conducted to investigate the neuroprotective effects of 20(S)-ginsenoside Rg3 on focal cerebral ischemia in rats. Middle cerebral artery occlusion (MCAO) model in male Wistar-Kyoto (WKY) rats was employed. The behavioral tests were used to evaluate the damage to central nervous system. The infarct area of brain was assessed in the brain slices stained with 2,3,5-triphenyltetrazolium chloride (TTC). Hydrogen clearance techniques were used to monitor regional cerebral blood flow (rCBF), spectrophotometric assay methods were used to determine the activities of superoxide dismutase (SOD) and glutathione-peroxidase (GSH-Px), contents of malondialdehyde (MDA) and adenosine triphosphate (ATP) of the brain. Furthermore, the respiratory control ratio (RCR=State 3/State 4) was assessed in the brain mitochondria. The results showed that sublingual vein injection of 20(S)-ginsenoside Rg3 at doses of 10 and 5 mg kg(-1), but not 2.5 mg kg(-1) exhibited significant neuroprotective effects on rats against focal cerebral ischemic injury by markedly decreasing neurological deficit scores, reducing the infarct area and enhancing the rCBF compared with the control group. At the same time, 20(S)-ginsenoside Rg3 significantly improved mitochondrial energy metabolism, antagonized decreases in SOD and GSH-Px activities and increase in MDA level induced by cerebral ischemia. All these findings suggest that 20(S)-ginsenoside Rg3 might provide neuroprotection against the cerebral ischemia-induced injury in rat brain through reducing lipid peroxides, scavenging free radicals and improving the energy metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
374
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
92-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:15644271-Adenosine Triphosphate, pubmed-meshheading:15644271-Analysis of Variance, pubmed-meshheading:15644271-Animals, pubmed-meshheading:15644271-Brain Chemistry, pubmed-meshheading:15644271-Brain Ischemia, pubmed-meshheading:15644271-Calcium Channel Blockers, pubmed-meshheading:15644271-Cerebral Infarction, pubmed-meshheading:15644271-Disease Models, Animal, pubmed-meshheading:15644271-Dose-Response Relationship, Drug, pubmed-meshheading:15644271-Ginsenosides, pubmed-meshheading:15644271-Glutathione Peroxidase, pubmed-meshheading:15644271-Infarction, Middle Cerebral Artery, pubmed-meshheading:15644271-Male, pubmed-meshheading:15644271-Malondialdehyde, pubmed-meshheading:15644271-Mitochondria, pubmed-meshheading:15644271-Neurologic Examination, pubmed-meshheading:15644271-Neuroprotective Agents, pubmed-meshheading:15644271-Nimodipine, pubmed-meshheading:15644271-Rats, pubmed-meshheading:15644271-Rats, Inbred WKY, pubmed-meshheading:15644271-Superoxide Dismutase, pubmed-meshheading:15644271-Time Factors
pubmed:year
2005
pubmed:articleTitle
Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats.
pubmed:affiliation
School of Pharmacy, Yantai University, Yantai, No. 32, Qingquan Road, Laishan District, Shangdong 264003, PR China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't