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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-5-15
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pubmed:abstractText |
The objective of the present study was to determine if periods of exposure would modify the developmental toxicity of butyl benzyl phthalate (BBP). Pregnant Wistar rats were given BBP at a dose of 2.0% in the diet on days 0-20, days 0-7, days 7-16 or days 16-20 of pregnancy. Food consumption and body weight gain were decreased in the pregnant rats given BBP. All dams given BBP on days 0-20 exhibited complete resorption of all the implanted embryos. Post-implantation loss in the pregnant rats given BBP on days 0-7 or 7-16 was higher than that in the control and pair-fed pregnant rats. No increase in post-implantation loss was found in the pregnant rats given BBP on days 16-20. Pre-implantation loss in the BBP-treated groups was comparable to the control and pair-fed groups. Striking teratogenicity was detected in fetuses of the dams given BBP on days 7-16. Cleft palate and fusion of the sternebrae were predominantly observed. About 95% of the fetuses in this group had cleft palate. The incidence of malformations in this group was significantly and markedly higher than that in the control and pair-fed groups.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0260-437X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1564254-Abnormalities, Drug-Induced,
pubmed-meshheading:1564254-Animals,
pubmed-meshheading:1564254-Bone and Bones,
pubmed-meshheading:1564254-Corpus Luteum,
pubmed-meshheading:1564254-Eating,
pubmed-meshheading:1564254-Embryo Implantation,
pubmed-meshheading:1564254-Embryonic and Fetal Development,
pubmed-meshheading:1564254-Female,
pubmed-meshheading:1564254-Kidney Pelvis,
pubmed-meshheading:1564254-Male,
pubmed-meshheading:1564254-Phthalic Acids,
pubmed-meshheading:1564254-Pregnancy,
pubmed-meshheading:1564254-Prenatal Exposure Delayed Effects,
pubmed-meshheading:1564254-Rats,
pubmed-meshheading:1564254-Rats, Inbred Strains,
pubmed-meshheading:1564254-Time Factors
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pubmed:year |
1992
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pubmed:articleTitle |
Effect of period of exposure on the developmental toxicity of butyl benzyl phthalate in rats.
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pubmed:affiliation |
National Institute of Hygienic Sciences, Osaka Branch, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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