Source:http://linkedlifedata.com/resource/pubmed/id/15642390
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2005-1-11
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| pubmed:abstractText |
Translocations involving chromosome 8 are the most common aberrations in B-cell non-Hodgkin lymphoma (B-NHL). The presence of the typical t(8;14)(q24;q32) or its variants has been confirmed in all cases of Burkitt lymphoma (BL), in some cases of Burkitt-like lymphoma (BLL), and in diffuse large B-cell lymphoma (DLBCL). The alterations lead to deregulated expression of c-myc protein by a chromosomal translocation joining C-MYC gene with sequences from immunoglobulin (Ig) enhancers. The C-MYC gene rearrangement plays an essential role in leukemogenesis of BL and probably plays a part in other aggressive NHLs. The present study was undertaken to compare the cytogenetic features in cases of BL, BLL, and DLBCL. We detected chromosomal aberrations by G-banding and fluorescence in situ hybridization (FISH) painting in 10 cases of aggressive B-NHL and used FISH to visualize the C-MYC gene rearrangement. Chromosome 8 was most frequently involved in structural aberrations (8/10 cases), and 4 cases showed the typical t(8;14)(q24;q32). Only two of 5 patients suspected of having BL fulfilled all the criteria for this diagnosis; in the others, chromosome 8 was aberrant, but the absence of C-MYC rearrangement or the results of flow cytometry excluded the diagnosis of BL. All BLL cases showed C-MYC overexpression, but only one had a rearrangement of the C-MYC gene; the remaining cases showed other aberrations of chromosome 8. This study indicates that the mechanisms of C-MYC activation involved in BLL can be different from that for the BL.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0165-4608
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
15
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| pubmed:volume |
156
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
114-21
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| pubmed:meshHeading |
pubmed-meshheading:15642390-Adolescent,
pubmed-meshheading:15642390-Adult,
pubmed-meshheading:15642390-Aged,
pubmed-meshheading:15642390-Chromosome Aberrations,
pubmed-meshheading:15642390-Chromosome Banding,
pubmed-meshheading:15642390-Chromosome Mapping,
pubmed-meshheading:15642390-Chromosomes, Human, Pair 14,
pubmed-meshheading:15642390-Chromosomes, Human, Pair 8,
pubmed-meshheading:15642390-Female,
pubmed-meshheading:15642390-Flow Cytometry,
pubmed-meshheading:15642390-Humans,
pubmed-meshheading:15642390-In Situ Hybridization, Fluorescence,
pubmed-meshheading:15642390-Karyotyping,
pubmed-meshheading:15642390-Lymphoma, B-Cell,
pubmed-meshheading:15642390-Male,
pubmed-meshheading:15642390-Middle Aged,
pubmed-meshheading:15642390-Translocation, Genetic,
pubmed-meshheading:15642390-Tumor Cells, Cultured
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| pubmed:year |
2005
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| pubmed:articleTitle |
Frequent aberrations of chromosome 8 in aggressive B-cell non-Hodgkin lymphoma.
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| pubmed:affiliation |
Cytogenetic Laboratory, The Memorial M. Sklodowska-Curie Cancer Centre and Institute, Roentgen Str 5, 02-781 Warsaw, Poland. barpien@coi.waw.pl
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| pubmed:publicationType |
Journal Article
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