|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003873,
umls-concept:C0022417,
umls-concept:C0024264,
umls-concept:C0024432,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0231449,
umls-concept:C0281481,
umls-concept:C0332120,
umls-concept:C0666743,
umls-concept:C0684224,
umls-concept:C0717758
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2005-1-13
|
|
pubmed:abstractText |
Treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF) antagonists is highly effective, but their mechanisms of action are not completely clear. Since anti-TNF therapy induces a decrease in synovial cellularity, this study focused on the modulation of RA synovial apoptosis following treatment with either soluble TNF receptor (etanercept) or TNF chimeric monoclonal antibody (infliximab).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0004-3591
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
52
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
61-72
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15641091-Adult,
pubmed-meshheading:15641091-Aged,
pubmed-meshheading:15641091-Antibodies, Monoclonal,
pubmed-meshheading:15641091-Antirheumatic Agents,
pubmed-meshheading:15641091-Apoptosis,
pubmed-meshheading:15641091-Arthritis, Rheumatoid,
pubmed-meshheading:15641091-Female,
pubmed-meshheading:15641091-Flow Cytometry,
pubmed-meshheading:15641091-Humans,
pubmed-meshheading:15641091-Immunoglobulin G,
pubmed-meshheading:15641091-Immunohistochemistry,
pubmed-meshheading:15641091-In Situ Nick-End Labeling,
pubmed-meshheading:15641091-Joints,
pubmed-meshheading:15641091-Lymphocytes,
pubmed-meshheading:15641091-Macrophages,
pubmed-meshheading:15641091-Male,
pubmed-meshheading:15641091-Middle Aged,
pubmed-meshheading:15641091-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:15641091-Synovial Fluid,
pubmed-meshheading:15641091-Synovial Membrane,
pubmed-meshheading:15641091-Treatment Outcome,
pubmed-meshheading:15641091-Tumor Necrosis Factors
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Evidence that anti-tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: extended report.
|
|
pubmed:affiliation |
Rheumatology Research Laboratory, CMM L8:04, Karolinska University Hospital, S-171 76 Stockholm, Sweden. Anca.Catrina@cmm.ki.se
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|
