Linked Life Data

15636426

Source:http://linkedlifedata.com/resource/pubmed/id/15636426

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2005-1-7
pubmed:abstractText
Oral DHEA administration to patients with hypoadrenalism, in addition to glucocorticoid and mineralcorticoid replacement, may improve both well-being and hormonal/metabolic parameters. Twenty patients (13 men, 7 women, 26-76 yr, 11 with Addison's disease, 9 with central hypoadrenalism) were recruited in a placebo-controlled, randomized study. Hormone levels, carbohydrate and lipid parameters, bone metabolism, body composition and psychological parameters were evaluated at baseline and after treatment with DHEA 50 mg/day or placebo for 4 months. After 4 months of DHEA administration, serum DHEAS levels raised both in men (from 0.71+/-0.18 to 8.28+/-1.66 micropmol/l, p<0.005) and in women (from 0.25+/-0.07 to 5.65+/-1.93 micromol/l, p<0.05). Only in hypoadrenal women an increase in testosterone (T; from 0.4+/-0.1 to 1.45+/-0.26 nmol/l, p<0.05) and androstenedione (A; from 0.86+/-0.34 to 2.05+/-0.29 nmol/l, p<0.05) levels was observed. In men no significant modifications in T and 17-hydroxyprogesterone (17-OHP) levels were found, whereas serum SHBG significantly decreased. As far as the metabolic parameters are concerned, only in patients with Addison's disease a significant decrease in total cholesterol and in low-density lipoproteins after 4 months of DHEA administration was found. No changes in glucose metabolism and insulin sensitivity were observed. In basal conditions, mean serum osteocalcin (OC) was normal and significantly decreased after DHEA treatment. A significant reduction in body fat mass percentage (BF%) after DHEA administration was observed. As far as well-being is concerned, DHEA replacement did not cause any relevant variation of subjective health scales and sexuality in both sexes. Our study confirms that DHEA may be beneficial for female patients with hypoadrenalism, mainly in restoring androgen levels. Concerning the health status, more sensitive and specific instruments to measure the effects of DHEA treatment could be necessary.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0391-4097
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
736-41
pubmed:meshHeading
pubmed-meshheading:15636426-Addison Disease, pubmed-meshheading:15636426-Adrenal Insufficiency, pubmed-meshheading:15636426-Adult, pubmed-meshheading:15636426-Affect, pubmed-meshheading:15636426-Aged, pubmed-meshheading:15636426-Androstenedione, pubmed-meshheading:15636426-Behavior, pubmed-meshheading:15636426-Blood Glucose, pubmed-meshheading:15636426-Body Composition, pubmed-meshheading:15636426-Bone and Bones, pubmed-meshheading:15636426-Dehydroepiandrosterone, pubmed-meshheading:15636426-Dehydroepiandrosterone Sulfate, pubmed-meshheading:15636426-Dietary Supplements, pubmed-meshheading:15636426-Double-Blind Method, pubmed-meshheading:15636426-Female, pubmed-meshheading:15636426-Hormones, pubmed-meshheading:15636426-Humans, pubmed-meshheading:15636426-Lipids, pubmed-meshheading:15636426-Male, pubmed-meshheading:15636426-Middle Aged, pubmed-meshheading:15636426-Sex Characteristics, pubmed-meshheading:15636426-Testosterone
pubmed:year
2004
pubmed:articleTitle
Effects of dehydroepiandrosterone (DHEA) supplementation on hormonal, metabolic and behavioral status in patients with hypoadrenalism.
pubmed:affiliation
Institute of Endocrine Science, University of Milan, Ospedale Maggiore IRCCS, Milan, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial